(Q39816367)

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Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults (English)

1 reference

Europe PubMed Central

14 September 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Wei Liu

1

1 reference

Europe PubMed Central

14 September 2017

David A Katz

2

1 reference

Europe PubMed Central

14 September 2017

Charles Locke

3

1 reference

Europe PubMed Central

14 September 2017

Dan Daszkowski

4

1 reference

Europe PubMed Central

14 September 2017

Yi Wang

5

1 reference

Europe PubMed Central

14 September 2017

Matthew J Rieser

6

1 reference

Europe PubMed Central

14 September 2017

Walid Awni

7

1 reference

Europe PubMed Central

14 September 2017

Gerard J Marek

8

1 reference

Europe PubMed Central

14 September 2017

Sandeep Dutta

9

1 reference

Europe PubMed Central

14 September 2017

publication date

21 February 2013

1 reference

Europe PubMed Central

14 September 2017

Clinical pharmacology in drug development

1 reference

Europe PubMed Central

14 September 2017

2

1 reference

Europe PubMed Central

14 September 2017

2

1 reference

Europe PubMed Central

14 September 2017

133-151

1 reference

Europe PubMed Central

14 September 2017

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Cortisol and Alzheimer's disease, I: Basal studies.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Hypothalamic-pituitary-adrenal system function in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

CSF cortisol in Alzheimer's disease and mild cognitive impairment.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Cortisol levels during human aging predict hippocampal atrophy and memory deficits.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Decreased memory performance in healthy humans induced by stress-level cortisol treatment.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Amygdala volume in patients receiving chronic corticosteroid therapy

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Stress reverses plasticity in the pathway projecting from the ventromedial prefrontal cortex to the basolateral amygdala.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Functional connectivity in the resting brain: a network analysis of the default mode hypothesis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Derivatization of ethinylestradiol with dansyl chloride to enhance electrospray ionization: application in trace analysis of ethinylestradiol in rhesus monkey plasma

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

21 January 2018

HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.5

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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