(Q39832619)

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Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27102208%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27102208%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

multiple myeloma

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based on heuristic

inferred from title

Pasquale M Barbaro

8

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2 April 2020

author name string

H Suen

1

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2 April 2020

R Brown

2

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2 April 2020

S Yang

3

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2 April 2020

C Weatherburn

4

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2 April 2020

P J Ho

5

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2 April 2020

N Woodland

6

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2 April 2020

N Nassif

7

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2 April 2020

C Bryant

9

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2 April 2020

D Hart

10

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2 April 2020

J Gibson

11

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2 April 2020

D Joshua

12

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2 April 2020

publication date

22 April 2016

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2 April 2020

1 reference

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2 April 2020

30

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2 April 2020

8

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2 April 2020

1716-1724

1 reference

Europe PubMed Central

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2 April 2020

CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Deciphering and reversing tumor immune suppression.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Molecular mechanisms for adaptive tolerance and other T cell anergy models

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Cellular senescence: when bad things happen to good cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

T cells in myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Assessment of monocytic component in acute myelomonocytic and monocytic/monoblastic leukemias by a chemiluminescent assay

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenstrom macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Telomere measurement by quantitative PCR

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

The structure, regulation, and function of ZAP-70.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Organization of proximal signal initiation at the TCR:CD3 complex

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Signalling molecules and cytokine production in T cells of multiple myeloma-increased abnormalities with advancing stage

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Molecular mechanisms involved in the aging of the T-cell immune response.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Reversal of human cellular senescence: roles of the p53 and p16 pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Activation of nuclear factor-kappa B signalling promotes cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Werner syndrome protein limits MYC-induced cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.84

21 January 2018

T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms that limit the in vitro proliferative potential of human CD8+ T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell receptor Vbeta repertoire usage and clonal expansion of T cells in chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic significance of T cell receptor beta gene rearrangements and idiotype-reactive T cells in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The failure of immune checkpoint blockade in multiple myeloma with PD-1 inhibitors in a phase 1 study

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8 + CD57 + CD28 − compartment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27102208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2016.84

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27102208%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

release_zikf53ill5cqtdoovxldpqltyi

1 reference

https://api.fatcat.wiki/v0/release/zikf53ill5cqtdoovxldpqltyi

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27102208%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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