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Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis.
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4405354
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3 March 2020
title
Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis
(English)
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PMC publication ID
4405354
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3 March 2020
main subject
apoptotic process
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phosphorylation
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author
Luca Scorrano
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4
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4405354
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3 March 2020
author name string
Aswin Pyakurel
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1
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4405354
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3 March 2020
Claudia Savoia
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2
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4405354
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3 March 2020
Daniel Hess
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3 March 2020
publication date
19 March 2015
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3 March 2020
published in
Molecular Cell
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4405354
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3 March 2020
volume
58
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3 March 2020
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2
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3 March 2020
page(s)
244-254
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3 March 2020
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PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
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Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.
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Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
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Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
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Structural basis of mitochondrial tethering by mitofusin complexes.
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22 September 2017
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22 September 2017
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
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22 September 2017
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
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22 September 2017
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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
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Interplay between MEK and PI3 kinase signaling regulates the subcellular localization of protein kinases ERK1/2 and Akt upon oxidative stress.
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20 August 2018
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death
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20 August 2018
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.
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20 August 2018
Erasure of kinase phosphorylation in astrocytes during oxygen-glucose deprivation is controlled by ATP levels and activation of phosphatases.
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20 August 2018
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
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12 December 2020
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Identifiers
DOI
10.1016/J.MOLCEL.2015.02.021
1 reference
stated in
Europe PubMed Central
PMC publication ID
4405354
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25801171%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PMC publication ID
4405354
1 reference
stated in
Europe PubMed Central
PMC publication ID
4405354
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25801171%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PubMed publication ID
25801171
1 reference
stated in
Europe PubMed Central
PMC publication ID
4405354
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25801171%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
ResearchGate publication ID
273790344
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