(Q39850882)

English

Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Jaafar N Haidar

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Yong Yu

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Zhiping Weng

4

1 reference

Europe PubMed Central

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9 February 2020

language of work or name

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publication date

1 August 2010

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Europe PubMed Central

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9 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

49

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

33

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

7050-7059

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

The modular organization of domain structures: insights into protein-protein binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Computational design of antibody-affinity improvement beyond in vivo maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

A comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Display, engineering, and applications of antigen-specific T cell receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Engineered T cell receptors and their potential in molecular medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Specificity on a knife-edge: the alphabeta T cell receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Making high-affinity T-cell receptors: a new class of targeted therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Long-range cooperative binding effects in a T cell receptor variable domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Insights into peptide-based vaccine design for cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

The modular architecture of protein-protein binding interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

A simple physical model for binding energy hot spots in protein-protein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Kinetic studies of protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Advances in surface plasmon resonance biosensor analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Effective energy function for proteins in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

22 September 2017

Determination of atomic desolvation energies from the structures of crystallized proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

15 June 2018

Additivity of mutational effects in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

15 June 2018

Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

T cell receptor binding transition states and recognition of peptide/MHC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

T cell receptor recognition via cooperative conformational plasticity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

Context-dependent mutations predominate in an engineered high-affinity single chain antibody fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

Directed evolution of human T-cell receptors with picomolar affinities by phage display.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

20 August 2018

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062070

2 December 2018

Experimental assignment of the structure of the transition state for the association of barnase and barstar

1 reference

https://pubmed.ncbi.nlm.nih.gov/20681514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP

1 reference

https://pubmed.ncbi.nlm.nih.gov/20681514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/20681514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding hot spots in the TEM1-BLIP interface in light of its modular architecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20681514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20681514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI901969A

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20681514%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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