(Q39856406)

English

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

scientific article published on 5 May 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

prostate cancer

1 reference

based on heuristic

inferred from title

Søren Brøgger Christensen

5

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Donald J Vander Griend

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Lizamma Antony

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Susan L Dalrymple

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Yi Xu

4

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Samuel R Denmeade

6

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

John T Isaacs

7

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

publication date

5 May 2009

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

1340-1349

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Cancer statistics, 2008

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Androgen receptor structural and functional elements: role and regulation in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Drug insight: role of the androgen receptor in the development and progression of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Regulation of androgen receptor activity by tyrosine phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Androgen receptor signaling is required for androgen-sensitive human prostate cancer cell proliferation and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Molecular determinants of resistance to antiandrogen therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Androgen Receptor Gene Amplification and Protein Expression in Recurrent Prostate Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Molecular characterization of human prostate carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Androgen receptor expression induces FGF2, FGF-binding protein production, and FGF2 release in prostate carcinoma cells: role of FGF2 in growth, survival, and androgen receptor down-modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

VCaP, a cell-based model system of human prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

22 September 2017

Role of calcium in the programmed death of rat prostatic glandular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

17 June 2018

Programmed death of nonproliferating androgen-independent prostatic cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

17 June 2018

Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

A transgenic mouse model for monitoring endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

A supramicromolar elevation of intracellular free calcium ([Ca(2+)](i)) is consistently required to induce the execution phase of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Androgen blocks apoptosis of hormone-dependent prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Calcium regulation of androgen receptor expression in the human prostate cancer cell line LNCaP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

20 August 2018

Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383025

2 December 2018

Activation of a Ca2+-Mg2+-dependent endonuclease as an early event in castration-induced prostatic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspase activity does not prevent the signaling phase of apoptosis in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of complete versus partial androgen withdrawal therapy for the treatment of prostatic cancer as studied in the Dunning R-3327 system of rat prostatic adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific properties of a C-terminal truncated androgen receptor detected in hormone refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment and validation of a microinjection method for kinetic analysis of [Ca2+]i in individual cells undergoing apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and role of growth arrest in programmed (apoptotic) death of prostatic cancer cells induced by thapsigargin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thapsigargin analogues for targeting programmed death of androgen-independent prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19417145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-08-1136

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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