(Q39875739)

15 September 2017

title

Influence of extended mutations of the HIV-1 transframe protein p6 on Nef-dependent viral replication and infectivity in vitro (English)

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15 September 2017

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Andreas Leiherer

1

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15 September 2017

Christine Ludwig

series ordinal

2

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15 September 2017

Ralf Wagner

series ordinal

3

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15 September 2017

language of work or name

English

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publication date

9 March 2009

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15 September 2017

number of pages

11

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inferred from page(s)

published in

Virology

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15 September 2017

volume

387

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15 September 2017

issue

1

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15 September 2017

page(s)

200-210

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

15 September 2017

cites work

2 references

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Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.

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Sequence-specific resonance assignments of the 1H-NMR spectra and structural characterization in solution of the HIV-1 transframe protein p6.

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The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro.

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Extended nucleocapsid protein is cleaved from the Gag-Pol precursor of human immunodeficiency virus type 1.

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Effects of human immunodeficiency virus type 1 transframe protein p6* mutations on viral protease-mediated Gag processing

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Interactions of processed Nef (58-206) with virion proteins of HIV type 1.

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Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines

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Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.

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Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity

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Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

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Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells

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Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability

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Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner

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Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response

7 January 2021

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Selection of human immunodeficiency virus type 1 variants with an insertion mutation in the p6(gag) and p6(pol) genes under highly active antiretroviral therapy

7 January 2021

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Analysis of near full-length genomic sequences of drug-resistant HIV-1 spreading among therapy-naïve individuals in Nagoya, Japan: amino acid mutations associated with viral replication activity

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Importance of protease cleavage sites within and flanking human immunodeficiency virus type 1 transframe protein p6* for spatiotemporal regulation of protease activation.

7 January 2021

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Analysis of insertions and deletions in the gag p6 region of diverse HIV type 1 strains.

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Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity

7 January 2021

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cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.

7 January 2021

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Functional association between the nef gene product and gag-pol region of HIV-1.

7 January 2021

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Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein

7 January 2021

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Contribution of the Gag-Pol transframe domain p6* and its coding sequence to morphogenesis and replication of human immunodeficiency virus type 1.

7 January 2021

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Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein

7 January 2021

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The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage

7 January 2021

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A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

7 January 2021

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Polymorphisms in p1-p6/p6* of HIV Type 1 Can Delay Protease Autoprocessing and Increase Drug Susceptibility

7 January 2021

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7 January 2021

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7 January 2021

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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2009.01.042

7 January 2021

gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2009.01.042

7 January 2021

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2009.01.042

7 January 2021

10.1016/J.VIROL.2009.01.042

Identifiers

DOI

1 reference

15 September 2017

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