(Q39877230)

English

GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability

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scholarly article

1 reference

Europe PubMed Central

15 September 2017

GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability (English)

1 reference

Europe PubMed Central

15 September 2017

phosphorylation

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author name string

Eli Kakiashvili

1

1 reference

Europe PubMed Central

15 September 2017

Pam Speight

2

1 reference

Europe PubMed Central

15 September 2017

Faiza Waheed

3

1 reference

Europe PubMed Central

15 September 2017

Romy Seth

4

1 reference

Europe PubMed Central

15 September 2017

Monika Lodyga

5

1 reference

Europe PubMed Central

15 September 2017

Susumu Tanimura

6

1 reference

Europe PubMed Central

15 September 2017

Michiaki Kohno

7

1 reference

Europe PubMed Central

15 September 2017

Ori D Rotstein

8

1 reference

Europe PubMed Central

15 September 2017

András Kapus

9

1 reference

Europe PubMed Central

15 September 2017

Katalin Szászi

10

1 reference

Europe PubMed Central

15 September 2017

language of work or name

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publication date

3 March 2009

1 reference

Europe PubMed Central

15 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

15 September 2017

284

1 reference

Europe PubMed Central

15 September 2017

17

1 reference

Europe PubMed Central

15 September 2017

11454-11466

1 reference

Europe PubMed Central

15 September 2017

Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.

1 reference

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22 September 2017

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.

1 reference

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22 September 2017

VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

1 reference

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22 September 2017

Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions

1 reference

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22 September 2017

Functions of TNF and its receptors in renal disease: distinct roles in inflammatory tissue injury and immune regulation

1 reference

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22 September 2017

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

1 reference

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22 September 2017

LIM kinases: function, regulation and association with human disease

1 reference

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22 September 2017

Coupling between apical and paracellular transport processes

1 reference

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Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

1 reference

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22 September 2017

Catching a GEF by its tail

1 reference

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22 September 2017

IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction

1 reference

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22 September 2017

Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Cofilin phosphatases and regulation of actin dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Rho GTPases: biochemistry and biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Biologics in the treatment of transplant rejection and ischemia/reperfusion injury: new applications for TNFalpha inhibitors?

1 reference

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22 September 2017

PAK4 mediates morphological changes through the regulation of GEF-H1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

The role of the cytoskeleton in cellular adhesion molecule expression in tumor necrosis factor-stimulated endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Tumor necrosis factor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Signal transduction by tumor necrosis factor and its relatives

1 reference

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22 September 2017

Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Modulation of tight junction structure and function by cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

22 September 2017

Tumor necrosis factor-alpha mRNA expression in lipopolysaccharide-stimulated rat kidney. Chronological analysis of localization

1 reference

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22 September 2017

Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

25 September 2017

Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma.

1 reference

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25 September 2017

Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

25 September 2017

Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

25 September 2017

Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Analysis of activated GAPs and GEFs in cell lysates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Hyperosmotic stress activates Rho: differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

15 June 2018

Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Tumor necrosis factor-alpha gene expression in diabetic nephropathy: relationship with urinary albumin excretion and effect of angiotensin-converting enzyme inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Depolarization induces Rho-Rho kinase-mediated myosin light chain phosphorylation in kidney tubular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-alpha generation and systemic release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

The Role of the Microtubules in Tumor Necrosis Factor-α–Induced Endothelial Cell Permeability

1 reference

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20 August 2018

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Effects of the inhibitors of dynamics of cytoskeletal structures on the development of apoptosis induced by the tumor necrosis factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

20 August 2018

Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis.

1 reference

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20 August 2018

Escherichia coli porin induces proinflammatory alterations in renal tubular cells.

1 reference

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20 August 2018

Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets

1 reference

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20 August 2018

Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670151

2 December 2018

Differential cellular immunolocalization of renal tumour necrosis factor-alpha production during ischaemia versus endotoxaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19261619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19261619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNF alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19261619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 alpha stimulated TNF alpha production by cultured human proximal tubular epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19261619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of tumour necrosis factor-alpha in renal dysfunction following mild haemorrhage in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19261619

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M805933200

1 reference

Europe PubMed Central

15 September 2017

release_ozgbam3n5va2nbxlztv2ma52yi

0 references

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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