(Q42808394)

English

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity

scientific article published on 11 November 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

author name string

Jeffrey C Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Shunhui Zhuang

2

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Tony H Nguyen

3

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Gerry R Boss

4

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Renate B Pilz

5

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

language of work or name

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publication date

11 November 2002

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Europe PubMed Central

PubMed publication ID

7 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

7 November 2017

278

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

2807-2818

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Ras activation in human breast cancer

1 reference

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21 January 2018

Hyperexpression of mitogen-activated protein kinase in human breast cancer

1 reference

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21 January 2018

RHO-GTPases and cancer

1 reference

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21 January 2018

Signaling to Rho GTPases

1 reference

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21 January 2018

A role for Rho in Ras transformation

1 reference

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21 January 2018

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway

1 reference

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21 January 2018

Signaling from Ras to Rac and beyond: not just a matter of GEFs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rac mediates growth factor-induced arachidonic acid release.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rapid recruitment of p120RasGAP and its associated protein, p190RhoGAP, to the cytoskeleton during integrin mediated cell-substrate interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Cadherin engagement regulates Rho family GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Differential activation of the Rac pathway by Ha-Ras and K-Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

A cytosolic protein catalyzes the release of GDP from p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Role of p120 Ras-GAP in directed cell movement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Increasing complexity of Ras signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rho GTPases are over-expressed in human tumors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Rho as a mediator of G protein-coupled receptor signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207943200

21 January 2018

Identifiers

10.1074/JBC.M207943200

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

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