(Q39886219)

15 September 2017

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances (English)

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15 September 2017

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Joel P Bercu

1

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15 September 2017

Stuart M Morton

2

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15 September 2017

J Thom Deahl

3

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15 September 2017

Vijay K Gombar

4

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15 September 2017

Courtney M Callis

5

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15 September 2017

Robert B L van Lier

6

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15 September 2017

language of work or name

English

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publication date

2 April 2010

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Regulatory Toxicology and Pharmacology

15 September 2017

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15 September 2017

57

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15 September 2017

2-3

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15 September 2017

300-306

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Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe.

15 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Toxicological and clinical computational analysis and the US FDA/CDER.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Application of the threshold of toxicological concern approach to ingredients in personal and household care products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

An impact analysis of the application of the threshold of toxicological concern concept to pharmaceuticals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Uncertainty in cancer risk estimates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A carcinogenic potency database of the standardized results of animal bioassays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Rodent carcinogens: setting priorities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Recent developments in the risk assessment of potentially genotoxic impurities in pharmaceutical drug substances

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Quantitative factors in chemical carcinogenesis: variation in carcinogenic potency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Threshold of toxicological concern (TTC) in food safety assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Drug-like properties and the causes of poor solubility and poor permeability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

In silico approaches to explore toxicity end points: issues and concerns for estimating human health effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Structure-activity relationship analysis tools: validation and applicability in predicting carcinogens.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Calculation of carcinogenic potency from long-term animal carcinogenesis experiments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Development of quantitative structure-activity relationship (QSAR) models to predict the carcinogenic potency of chemicals I. Alternative toxicity measures as an estimator of carcinogenic potency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Three new consensus QSAR models for the prediction of Ames genotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A multiple in silico program approach for the prediction of mutagenicity from chemical structure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

10.1016/J.YRTPH.2010.03.010

7 January 2021

Identifiers

DOI

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15 September 2017

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