(Q39896274)

English

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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pancreatic cancer

1 reference

based on heuristic

inferred from title

7

object named as

William A Denny

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Brian D. Palmer

5

object named as

Brian D Palmer

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Leslie A Parsels

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Meredith A Morgan

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Daria M Tanska

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Joshua D Parsels

4

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

R John Booth

6

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Christine E Canman

8

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Alan J Kraker

9

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Theodore S Lawrence

10

1 reference

Europe PubMed Central

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15 September 2017

Jonathan Maybaum

11

1 reference

Europe PubMed Central

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15 September 2017

language of work or name

1 reference

based on heuristic

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publication date

1 January 2009

1 reference

Europe PubMed Central

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15 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

45-54

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Inhibitors of checkpoint kinases: from discovery to the clinic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Identification of pancreatic cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Chk1 inhibitors for novel cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Development of cell cycle active drugs for the treatment of gastrointestinal cancers: a new approach to cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

G2 checkpoint abrogators as anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Cell cycle checkpoints and their impact on anticancer therapeutic strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

22 September 2017

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

15 June 2018

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

15 June 2018

The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

15 June 2018

Selective targeting of homologous DNA recombination repair by gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

20 August 2018

BRCA2-dependent and independent formation of RAD51 nuclear foci.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

20 August 2018

Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730564

20 August 2018

Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19139112

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-08-0662

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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