(Q39916287)

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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression

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Europe PubMed Central

15 September 2017

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression (English)

1 reference

Europe PubMed Central

15 September 2017

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Mark J. Crabtree

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Mark J Crabtree

1

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Keith M Channon

7

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author name string

Amy L Tatham

2

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Europe PubMed Central

15 September 2017

Yasir Al-Wakeel

3

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Europe PubMed Central

15 September 2017

Nicholas Warrick

4

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Europe PubMed Central

15 September 2017

Ashley B Hale

5

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Europe PubMed Central

15 September 2017

Shijie Cai

6

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Europe PubMed Central

15 September 2017

Nicholas J Alp

8

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Europe PubMed Central

15 September 2017

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publication date

14 November 2008

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Europe PubMed Central

15 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

15 September 2017

284

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Europe PubMed Central

15 September 2017

1136-1144

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Europe PubMed Central

15 September 2017

2

1 reference

Europe PubMed Central

15 September 2017

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1 reference

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Hypercholesterolemia increases endothelial superoxide anion production

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Superoxide and peroxynitrite in atherosclerosis

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Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

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Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells

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The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

1 reference

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21 January 2018

Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.

1 reference

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21 January 2018

Origin of superoxide production by endothelial nitric oxide synthase

1 reference

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21 January 2018

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

1 reference

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21 January 2018

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice

1 reference

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21 January 2018

Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase

1 reference

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21 January 2018

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1 reference

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Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia

1 reference

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21 January 2018

Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer

1 reference

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21 January 2018

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells

1 reference

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21 January 2018

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

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21 January 2018

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

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Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue

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21 January 2018

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

1 reference

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21 January 2018

The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

The reaction of no with superoxide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

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21 January 2018

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805403200

21 January 2018

Identifiers

10.1074/JBC.M805403200

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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