(Q39942436)

15 September 2017

Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide (English)

1 reference

Utta Berchner-Pfannschmidt

15 September 2017

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1 reference

1

object named as

Utta Berchner-Pfannschmidt

1 reference

15 September 2017

8

Joachim Fandrey

1 reference

15 September 2017

Suzan Tug

2

1 reference

15 September 2017

Buena Trinidad

3

1 reference

15 September 2017

Felix Oehme

4

1 reference

15 September 2017

Hatice Yamac

5

1 reference

15 September 2017

Christoph Wotzlaw

6

1 reference

15 September 2017

Ingo Flamme

7

1 reference

15 September 2017

language of work or name

English

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publication date

6 September 2008

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Journal of Biological Chemistry

15 September 2017

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15 September 2017

283

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15 September 2017

46

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15 September 2017

31745-31753

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

15 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Formation of S-nitrosothiols from regiospecific reaction of thiols with N-nitrosotryptophan derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

Pericellular PO2 and O2 consumption in monolayer cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804390200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804390200

1 reference

15 September 2017

1 reference