(Q39955685)

15 September 2017

title

A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997. (English)

1 reference

Streptomyces hygroscopicus

15 September 2017

main subject

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inferred from

reverse claim

[(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

1 reference

Yonghai Li

1

1 reference

15 September 2017

Weiqing He

2

1 reference

15 September 2017

Yucheng Wang

3

1 reference

15 September 2017

Yiguang Wang

4

1 reference

15 September 2017

Rongguang Shao

5

1 reference

15 September 2017

publication date

1 June 2008

1 reference

full work available at URL

15 September 2017

https://www.nature.com/articles/ja200849.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1038/ja.2008.49?email=unpaywall_01@example.com

published in

The Journal of Antibiotics

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15 September 2017

volume

61

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15 September 2017

issue

6

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15 September 2017

page(s)

347-355

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https://api.unpaywall.org/v2/10.1038/ja.2008.49?email=unpaywall_01@example.com

15 September 2017

1 reference

19 March 2024

access restriction status

open access

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inferred from online access status

exact match

https://scigraph.springernature.com/pub.10.1038/ja.2008.49

0 references

cites work

Molecular chaperone Hsp90 is important for vaccinia virus growth in cells

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

[Cloning and analysis of geldanamycin partial biosynthetic gene cluster of Streptomyces hygroscopicus 17997].

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Inhibitors of the HSP90 molecular chaperone: current status

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Geldanamycin, a new antibiotic

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Characterization of sannamycin A-nonproducing mutants of Streptomyces sannanensis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Rifamycin-mode of action, resistance, and biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2008.49

7 January 2021

Identifiers

DOI

10.1038/JA.2008.49

1 reference

15 September 2017

1 reference