(Q39958640)

15 September 2017

title

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity (English)

1 reference

15 September 2017

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4

Gregg L Semenza

1 reference

15 September 2017

Richard Sullivan

1

1 reference

15 September 2017

Geneviève C Paré

series ordinal

2

1 reference

15 September 2017

Lisa J Frederiksen

series ordinal

3

1 reference

15 September 2017

Charles H Graham

series ordinal

5

1 reference

15 September 2017

publication date

1 July 2008

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Molecular Cancer Therapeutics

15 September 2017

published in

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15 September 2017

volume

7

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15 September 2017

issue

7

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15 September 2017

page(s)

1961-1973

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Extension of life-span by introduction of telomerase into normal human cells

15 September 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

HIF1alpha delays premature senescence through the activation of MIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Targeting HIF-1 for cancer therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

The identification of senescence-specific genes during the induction of senescence in prostate cancer cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

HIF-1-mediated activation of telomerase in cervical cancer cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia and HIF-1alpha protect A549 cells from drug-induced apoptosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Why do cancers have high aerobic glycolysis?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Nitric oxide-mediated regulation of chemosensitivity in cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1535-7163.MCT-08-0198

Identifiers

DOI

10.1158/1535-7163.MCT-08-0198

1 reference

15 September 2017

1 reference