(Q40005542)

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Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18322105%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing (English)

1 reference

Europe PubMed Central

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3 January 2020

phosphorylation

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author name string

Yi Wen

1

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3 January 2020

Emmanuel Planel

2

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3 January 2020

Mathieu Herman

3

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3 January 2020

Helen Y Figueroa

4

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3 January 2020

Lili Wang

5

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3 January 2020

Li Liu

6

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3 January 2020

Lit-Fui Lau

7

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3 January 2020

Wai Haung Yu

8

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3 January 2020

Karen E Duff

9

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3 January 2020

language of work or name

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publication date

1 March 2008

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3 January 2020

Journal of Neuroscience

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3 January 2020

28

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3 January 2020

10

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3 January 2020

2624-2632

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3 January 2020

Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau neurofibrillary pathology and microtubule stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5 in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MARKing tau for tangles and toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue processing prior to protein analysis and amyloid-beta quantitation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ELISA method for measurement of amyloid-beta levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase controls early and late events in mammalian cell division

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Her-2 targeted therapy: beyond breast cancer and trastuzumab

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuregulin-1 and myelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schizophrenia genes - famine to feast

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Networking with proline-directed protein kinases implicated in tau phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation of tau in PHF

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuregulins and their receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling: a common theme in animal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5245-07.2008

1 reference

Europe PubMed Central

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3 January 2020

1 reference

Europe PubMed Central

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3 January 2020

1 reference

Europe PubMed Central

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3 January 2020

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