(Q40013409)

English

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.

scientific article published on 14 February 2008

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scholarly article

1 reference

Europe PubMed Central

16 September 2017

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. (English)

1 reference

Europe PubMed Central

16 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

lymphoblastic leukemia

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

L Gu

1

1 reference

Europe PubMed Central

16 September 2017

N Zhu

2

1 reference

Europe PubMed Central

16 September 2017

H W Findley

3

1 reference

Europe PubMed Central

16 September 2017

M Zhou

4

1 reference

Europe PubMed Central

16 September 2017

publication date

14 February 2008

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

22

1 reference

Europe PubMed Central

16 September 2017

4

1 reference

Europe PubMed Central

16 September 2017

730-739

1 reference

Europe PubMed Central

16 September 2017

https://scigraph.springernature.com/pub.10.1038/leu.2008.11

0 references

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Treatment of acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Live or let die: the cell's response to p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

The MDM2 gene amplification database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

High risk lymphoblastic leukemia in children: prognostic factors and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

22 September 2017

DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

25 September 2017

Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

17 June 2018

Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

17 June 2018

Inactivation of the p53 gene expression by a splice donor site mutation in a human T-cell leukemia cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

17 June 2018

Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

In vitro drug sensitivity and apoptosis induction in newly diagnosed pediatric acute lymphoblastic leukemia: correlation with overall survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

The IARC TP53 database: new online mutation analysis and recommendations to users

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477706

20 August 2018

Cellular expression of MDM2 and p53 in childhood leukemias with poor prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDM2 and p53 in childhood acute lymphoblastic leukemia: higher expression in childhood leukemias with poor prognosis compared to long-term survivors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the p53 gene in lymphoid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human MDM-2 oncogene is overexpressed in leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of MDM2 in acute childhood lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of class II beta-tubulin expression by tumor suppressor p53 protein in mouse melanoma cells in response to Vinca alkaloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18273046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2008.11

1 reference

Europe PubMed Central

16 September 2017

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0 references

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

ResearchGate publication ID

0 references

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