(Q40048806)

16 September 2017

Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity (English)

1 reference

16 September 2017

2

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Renato V. Iozzo

9

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author name string

Benjamin P Woodall

1

1 reference

16 September 2017

Rex A Iozzo

3

1 reference

16 September 2017

Johannes A Eble

4

1 reference

16 September 2017

Stephan Niland

5

1 reference

16 September 2017

Thomas Krieg

6

1 reference

16 September 2017

Beate Eckes

7

1 reference

16 September 2017

Ambra Pozzi

8

1 reference

16 September 2017

language of work or name

English

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publication date

15 November 2007

1 reference

Journal of Biological Chemistry

16 September 2017

1 reference

16 September 2017

283

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16 September 2017

2335-2343

1 reference

16 September 2017

4

1 reference

Angiogenesis in life, disease and medicine

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Role of perlecan in skeletal development and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan: how does one molecule do so many things?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Heparan sulfate: a complex polymer charged with biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan--a multifunctional extracellular proteoglycan scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Basement membrane proteoglycans: from cellar to ceiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Fibroblast growth factor-binding protein is a novel partner for perlecan protein core

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endogenous inhibitors of angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Matrix revolutions: "tails" of basement-membrane components with angiostatic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD-independent disintegrin and potent inhibitor of cell adhesion to collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Structural basis of collagen recognition by integrin alpha2beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

A reevaluation of integrins as regulators of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan: a gem of a proteoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan signaling: helping hedgehog stimulate prostate cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Collagen-binding integrins as pharmaceutical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Crystal structure of the I domain from integrin alpha2beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Integrins: bidirectional, allosteric signaling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Echovirus 1 interaction with the human very late antigen-2 (integrin alpha2beta1) I domain. Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

LG/LNS domains: multiple functions -- one business end?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Domain structure and organisation in extracellular matrix proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Integrins: roles in cancer development and as treatment targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708364200

21 January 2018

Identifiers

DOI

10.1074/JBC.M708364200

1 reference

16 September 2017

1 reference