(Q40049552)

English

Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation

scientific article published on 20 November 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

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inferred from title

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Chun-Te Chiang

1

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Tzong-Der Way

2

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Shang-Jie Tsai

3

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Jen-Kun Lin

4

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Europe PubMed Central

PubMed publication ID

16 September 2017

language of work or name

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publication date

20 November 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

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Europe PubMed Central

PubMed publication ID

16 September 2017

581

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

5735-5742

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Fatty acid synthase, a proficient multifunctional enzyme

1 reference

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21 January 2018

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

1 reference

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21 January 2018

Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

1 reference

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21 January 2018

Fatty acid synthase and cancer: new application of an old pathway

1 reference

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21 January 2018

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

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Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

1 reference

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21 January 2018

Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.

1 reference

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21 January 2018

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

1 reference

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21 January 2018

Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of solasodine glycosides

1 reference

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21 January 2018

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

1 reference

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21 January 2018

A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells

1 reference

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21 January 2018

Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression

1 reference

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21 January 2018

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

1 reference

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21 January 2018

Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.

1 reference

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21 January 2018

Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin

1 reference

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21 January 2018

Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

1 reference

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21 January 2018

Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity

1 reference

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Phytoestrogens and breast cancer risk. Review of the epidemiological evidence

1 reference

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Mechanisms of cancer chemoprevention by soy isoflavone genistein

1 reference

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Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells.

1 reference

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21 January 2018

Cancer. Addiction to oncogenes--the Achilles heal of cancer

1 reference

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21 January 2018

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

1 reference

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21 January 2018

Targeting the AKT protein kinase for cancer chemoprevention

1 reference

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21 January 2018

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

1 reference

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21 January 2018

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

1 reference

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21 January 2018

Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

1 reference

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The JNK signal transduction pathway

1 reference

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The functional contrariety of JNK

1 reference

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Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells

1 reference

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21 January 2018

Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1158/1055-9965.1392.13.8

Identifiers

10.1016/J.FEBSLET.2007.11.021

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

release_cjnx4fkgxrds3os2h56w3v6xr4

1 reference

https://api.fatcat.wiki/v0/release/cjnx4fkgxrds3os2h56w3v6xr4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

ResearchGate publication ID

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