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Hypoxia and the unfolded protein response.
scientific article published on January 2007
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Europe PubMed Central
PubMed publication ID
17998059
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998059%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
title
Hypoxia and the unfolded protein response
(English)
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Europe PubMed Central
PubMed publication ID
17998059
reference URL
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10 January 2020
author
Costas Koumenis
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1
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Europe PubMed Central
PubMed publication ID
17998059
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10 January 2020
Jiangbin Ye
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3
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PubMed publication ID
17998059
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10 January 2020
Albert C. Koong
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5
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Europe PubMed Central
PubMed publication ID
17998059
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10 January 2020
author name string
Meixia Bi
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2
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PubMed publication ID
17998059
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10 January 2020
Douglas Feldman
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4
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Europe PubMed Central
PubMed publication ID
17998059
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10 January 2020
language of work or name
English
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publication date
1 January 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17998059
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998059%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
published in
Methods in Enzymology
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Europe PubMed Central
PubMed publication ID
17998059
reference URL
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10 January 2020
volume
435
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Europe PubMed Central
PubMed publication ID
17998059
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10 January 2020
page(s)
275-293
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Europe PubMed Central
PubMed publication ID
17998059
reference URL
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retrieved
10 January 2020
cites work
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells
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7 January 2021
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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.
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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
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Crossref
reference URL
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7 January 2021
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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
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Crossref
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7 January 2021
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Activating transcription factor 4 is translationally regulated by hypoxic stress
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Crossref
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7 January 2021
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Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
1 reference
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7 January 2021
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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7 January 2021
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Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae
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7 January 2021
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Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
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Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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The unfolded protein response: a novel component of the hypoxic stress response in tumors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancers
1 reference
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Crossref
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7 January 2021
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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Perk is essential for translational regulation and cell survival during the unfolded protein response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Regulated translation initiation controls stress-induced gene expression in mammalian cells
1 reference
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7 January 2021
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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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7 January 2021
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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Orchestrating the unfolded protein response in health and disease
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Targeting XBP-1 as a novel anti-cancer strategy.
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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inferred from DOI database lookup
Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stress induction of GRP78/BiP and its role in cancer.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-induced energy stress regulates mRNA translation and cell growth
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
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inferred from DOI database lookup
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The role of the unfolded protein response in tumour development: friend or foe?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is activated for cell survival after endoplasmic reticulum stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational control in the endoplasmic reticulum stress response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ER stress and the unfolded protein response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative protein folding in eukaryotes: mechanisms and consequences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical basis of oxidative protein folding in the endoplasmic reticulum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of the hypoxic response through regulation of mRNA translation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biological consequences of tumor hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935014-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0076-6879(07)35014-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17998059
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998059%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
PubMed publication ID
17998059
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17998059
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998059%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
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