(Q40058893)

English

R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy.

scientific article published on 2 November 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

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inferred from title

5

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9 January 2020

author name string

A Dey

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

E T Wong

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

C F Cheok

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

V Tergaonkar

4

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9 January 2020

publication date

2 November 2007

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9 January 2020

Cell Death & Differentiation

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

15

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9 January 2020

2

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9 January 2020

263-273

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9 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402257

0 references

Transcriptional cross talk between NF-kappaB and p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Shaping the nuclear action of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Integrating cell-signalling pathways with NF-kappaB and IKK function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Inflammation and cancer: how hot is the link?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

NFkappaB pathway: a good signaling paradigm and therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Inhibitors of NF-kappaB signaling: 785 and counting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Activation of p53 by roscovitine-mediated suppression of MDM2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Nuclear factor-kappaB: the enemy within

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

21 January 2018

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

7 January 2021

based on heuristic

inferred from DOI database lookup

An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 is a suppressor of inflammatory response in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402257

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.CDD.4402257

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975552%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

ResearchGate publication ID

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