(Q40059036)

English

The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes

scientific article published on November 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

author name string

Priscilla L K Lim

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Jianchao Liu

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Mei L Go

3

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Urs A Boelsterli

4

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

publication date

1 November 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Toxicological Sciences

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

101

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

341-349

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome C and turning on the peroxidase activity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Troglitazone and liver injury: in search of answers

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Role of mitogen-activated protein kinase (MAPK) in troglitazone-induced osteoblastic cell death

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mechanisms of action of cyclosporine.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Troglitazone-induced intracellular oxidative stress in rat hepatoma cells: a flow cytometric assessment

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondrial oxidative stress: implications for cell death

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mechanisms of troglitazone hepatotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Prooxidant and antioxidant activity of vitamin E analogues and troglitazone

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Effects of troglitazone on HepG2 viability and mitochondrial function

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Toxic effect of troglitazone on cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM273

21 January 2018

Identifiers

10.1093/TOXSCI/KFM273

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

ResearchGate publication ID

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