(Q40066046)

17 September 2017

title

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects (English)

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17 September 2017

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6

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Claudio Russo

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Stefano Thellung

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Stefano Thellung

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Tullio Florio

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Tullio Florio

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author name string

Katia Chiovitti

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17 September 2017

Valentina Villa

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17 September 2017

Domenico Paludi

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Angelo Perico

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Adriana Ianieri

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Domenico Di Cola

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Alberto Vergara

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Antonio Aceto

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17 September 2017

language of work or name

English

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publication date

18 October 2007

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Journal of Neurochemistry

17 September 2017

published in

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17 September 2017

volume

103

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issue

6

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17 September 2017

page(s)

2597-2609

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Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis

17 September 2017

cites work

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Folding of prion protein to its native alpha-helical conformation is under kinetic control

21 January 2018

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In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc).

21 January 2018

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Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.

21 January 2018

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

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Truncated forms of the human prion protein in normal brain and in prion diseases.

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Prion diseases: what is the neurotoxic molecule?

21 January 2018

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Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

21 January 2018

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Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04965.X

Neurotoxicity of a prion protein fragment

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

21 January 2018

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An unusual soluble beta-turn-rich conformation of prion is involved in fibril formation and toxic to neuronal cells.

21 January 2018

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Disease-associated prion protein oligomers inhibit the 26S proteasome

21 January 2018

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The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites

21 January 2018

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Synthetic mammalian prions

21 January 2018

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High-level expression and characterization of a purified 142-residue polypeptide of the prion protein

21 January 2018

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Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures

21 January 2018

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Novel proteinaceous infectious particles cause scrapie

21 January 2018

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Molecular biology of prion diseases

21 January 2018

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21 January 2018

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Scrapie prions aggregate to form amyloid-like birefringent rods

21 January 2018

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Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

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Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126.

21 January 2018

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Association of an 11-12 kDa protease-resistant prion protein fragment with subtypes of dura graft-associated Creutzfeldt-Jakob disease and other prion diseases

21 January 2018

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21 January 2018

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Aggregation and fibrillization of the recombinant human prion protein huPrP90-231.

21 January 2018

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Toxic proteins in neurodegenerative disease

21 January 2018

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Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

21 January 2018

1 reference

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p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04965.X

Alternative prion structural changes revealed by high pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04965.X

Physical studies of conformational plasticity in a recombinant prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04965.X

Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04965.X

Multiple folding pathways for heterologously expressed human prion protein

21 January 2018

1 reference

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Amyloid Fibrils of Mammalian Prion Protein Are Highly Toxic to Cultured Cells and Primary Neurons

21 January 2018

1 reference

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10.1111/J.1471-4159.2007.04965.X

21 January 2018

Identifiers

DOI

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17 September 2017

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