(Q40070793)

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STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression (English)

1 reference

Europe PubMed Central

17 September 2017

Mariusz A Wasik

4

object named as

Mariusz A Wasik

1 reference

Europe PubMed Central

17 September 2017

author name string

Qian Zhang

1

1 reference

Europe PubMed Central

17 September 2017

Hong Y Wang

2

1 reference

Europe PubMed Central

17 September 2017

Xiaobin Liu

3

1 reference

Europe PubMed Central

17 September 2017

language of work or name

0 references

publication date

7 October 2007

1 reference

Europe PubMed Central

17 September 2017

Nature Medicine

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Europe PubMed Central

17 September 2017

13

1 reference

Europe PubMed Central

17 September 2017

1341-1348

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Europe PubMed Central

17 September 2017

11

1 reference

Europe PubMed Central

17 September 2017

https://scigraph.springernature.com/pub.10.1038/nm1659

0 references

Roles and regulation of stat family transcription factors in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

21 January 2018

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

21 January 2018

Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

21 January 2018

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transducer and activator of transcription 5 (STAT5).

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene silencing in cancer in association with promoter hypermethylation

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Methyl CpG binding proteins: coupling chromatin architecture to gene regulation

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of STAT signalling by proteolytic processing

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the human STAT5A and STAT5B promoters: evidence of a positive and negative mechanism of transcriptional regulation.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-range chromatin regulatory interactions in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Communication over a large distance: enhancers and insulators

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat5 tetramer formation is associated with leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

The STATs of cancer--new molecular targets come of age

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic myeloid leukemia: a model for oncology

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Epigenetic targets in hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

1 reference

https://api.crossref.org/works/10.1038%2FNM1659

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

1 reference

Europe PubMed Central

17 September 2017

1 reference

Europe PubMed Central

17 September 2017

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