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Identification of an intramolecular interaction important for the regulation of GIT1 functions.
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PMC publication ID
2096589
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
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8 January 2020
title
Identification of an intramolecular interaction important for the regulation of GIT1 functions
(English)
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PMC publication ID
2096589
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8 January 2020
author
Ivanmatteo De Curtis
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4
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2096589
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8 January 2020
author name string
Antonio Totaro
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1
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PMC publication ID
2096589
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8 January 2020
Simona Paris
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2
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2096589
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8 January 2020
Claudia Asperti
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3
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2096589
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8 January 2020
publication date
26 September 2007
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2096589
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8 January 2020
published in
Molecular Biology of the Cell
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Europe PubMed Central
PMC publication ID
2096589
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
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8 January 2020
volume
18
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PMC publication ID
2096589
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
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8 January 2020
issue
12
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PMC publication ID
2096589
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retrieved
8 January 2020
page(s)
5124-5138
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PMC publication ID
2096589
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
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8 January 2020
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Europe PubMed Central
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Identification of phosphorylation sites in GIT1.
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PubMed Central
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Phosphorylation of serine 709 in GIT1 regulates protrusive activity in cells
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22 September 2017
betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1
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Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics
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22 September 2017
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
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The multifunctional GIT family of proteins
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The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins
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Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1
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Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes.
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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
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Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness
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GIT1 is a scaffold for ERK1/2 activation in focal adhesions
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22 September 2017
Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway
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A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
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The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors
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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
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22 September 2017
GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor
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22 September 2017
GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor
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22 September 2017
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts
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PubMed Central
reference URL
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22 September 2017
ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth
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Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
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22 September 2017
Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2
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22 September 2017
The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
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22 September 2017
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration
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Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway
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GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration
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The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
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22 September 2017
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis
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22 September 2017
Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase
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22 September 2017
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).
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22 September 2017
Cell migration: GAPs between membrane traffic and the cytoskeleton
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22 September 2017
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery
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22 September 2017
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly
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PubMed Central
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22 September 2017
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6
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22 September 2017
The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton
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22 September 2017
Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta
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22 September 2017
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
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22 September 2017
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096589
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22 September 2017
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096589
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22 September 2017
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding
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PubMed Central
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25 September 2017
Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading
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25 September 2017
p95-APP1 links membrane transport to Rac-mediated reorganization of actin
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096589
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15 June 2018
EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization
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15 June 2018
S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096589
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20 August 2018
Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1.
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20 August 2018
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
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20 August 2018
Molecular mechanisms regulating the subcellular localization of p95-APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface
1 reference
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PubMed
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12 December 2020
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Differential distribution of two cytoplasmic variants of the alpha 6 beta 1 integrin laminin receptor in the ventral plasma membrane of embryonic fibroblasts
1 reference
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1091/MBC.E07-06-0550
1 reference
stated in
Europe PubMed Central
PMC publication ID
2096589
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
PMC publication ID
2096589
1 reference
stated in
Europe PubMed Central
PMC publication ID
2096589
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
PubMed publication ID
17898078
1 reference
stated in
Europe PubMed Central
PMC publication ID
2096589
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17898078%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
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