(Q40084369)

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Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

scientific article published on 22 August 2017

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28 March 2020

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine (English)

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28 March 2020

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Consuelo Gajate

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28 March 2020

Alberto Jiménez

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28 March 2020

Rubén E Varela-Miranda

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28 March 2020

Álvaro Cuesta-Marbán

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28 March 2020

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28 March 2020

Faustino Mollinedo

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28 March 2020

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Janny A Villa-Pulgarín

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28 March 2020

Javier Botet

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28 March 2020

Nicole Justies

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28 March 2020

Manuel Modolell

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28 March 2020

José L Revuelta

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22 August 2017

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28 March 2020

PLoS Neglected Tropical Diseases

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28 March 2020

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28 March 2020

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28 March 2020

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28 March 2020

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22 August 2017

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Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

1 reference

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Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance

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Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

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Leishmaniasis worldwide and global estimates of its incidence

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Exogenous ether lipids predominantly target mitochondria

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Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.

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Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

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Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane

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Selective Fusion of Azurophilic Granules with Leishmania-containing Phagosomes in Human Neutrophils

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Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment

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Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

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Lipid raft-targeted therapy in multiple myeloma.

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Potential involvement of F0F1-ATP(synth)ase and reactive oxygen species in apoptosis induction by the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines : a mechanism for induction of apoptosis via the 18 kDa mitochondrial tran

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Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

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Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

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Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

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15 June 2018

Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

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Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis.

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Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids

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Leishmania tarentolae: utility as an in vitro model for screening of antileishmanial agents

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20 August 2018

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

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20 August 2018

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Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

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20 August 2018

Edelfosine is incorporated into rafts and alters their organization

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20 August 2018

Lipid raft proteome reveals ATP synthase complex in the cell surface.

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20 August 2018

Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568728

20 August 2018

The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568728

20 August 2018

Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568728

20 August 2018

Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0005805

21 January 2018

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0005805

21 January 2018

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0005805

21 January 2018

Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X(L) expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of cyclodextrins for manipulating cellular cholesterol content

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of N(G)-hydroxyl-L-arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular trafficking of cholesterol monitored with a cyclodextrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Editorial: Antitumor alkylphospholipid analogs: a promising and growing family of synthetic cell membrane-targeting molecules for cancer treatment)

1 reference

https://pubmed.ncbi.nlm.nih.gov/28829771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0005805

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28829771%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28829771%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28829771%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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