(Q40096614)

17 September 2017

Reduced seed region-based off-target activity with lentivirus-mediated RNAi (English)

1 reference

17 September 2017

Richard A Klinghoffer

1

1 reference

17 September 2017

Jill Magnus

2

1 reference

17 September 2017

Janell Schelter

3

1 reference

17 September 2017

Michele Mehaffey

4

1 reference

17 September 2017

Casey Coleman

5

1 reference

17 September 2017

Michele A Cleary

6

1 reference

17 September 2017

language of work or name

English

0 references

publication date

26 March 2010

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17 September 2017

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17 September 2017

16

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17 September 2017

5

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17 September 2017

879-884

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A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling

17 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Prevalence of off-target effects in Drosophila RNA interference screens

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Expression profiling reveals off-target gene regulation by RNAi

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Specificity of short interfering RNA determined through gene expression signatures

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Potency of siRNA versus shRNA mediated knockdown in vivo

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

Synthetic shRNAs as potent RNAi triggers.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856882

20 August 2018

Identifiers

DOI

10.1261/RNA.1977810

1 reference

17 September 2017

1 reference

17 September 2017

1 reference