(Q51562164)

7 April 2018

title

Synthetic shRNAs as potent RNAi triggers. (English)

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7

Gregory J Hannon

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author name string

Despina Siolas

1

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7 April 2018

Cara Lerner

2

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Julja Burchard

3

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7 April 2018

Wei Ge

4

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7 April 2018

Peter S Linsley

5

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7 April 2018

Patrick J Paddison

6

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Michele A Cleary

8

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7 April 2018

publication date

26 December 2004

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7 April 2018

published in

Nature Biotechnology

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7 April 2018

volume

23

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issue

2

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page(s)

227-231

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https://scigraph.springernature.com/pub.10.1038/nbt1052

exact match

0 references

cites work

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Argonaute2, a link between genetic and biochemical analyses of RNAi

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Crystal structure of Argonaute and its implications for RISC slicer activity

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Argonaute2 is the catalytic engine of mammalian RNAi

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

21 January 2018

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 January 2018

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

21 January 2018

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Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

21 January 2018

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A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila

21 January 2018

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RISC assembly defects in the Drosophila RNAi mutant armitage.

21 January 2018

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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

21 January 2018

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Nuclear export of microRNA precursors

21 January 2018

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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

21 January 2018

1 reference

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

21 January 2018

1 reference

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

21 January 2018

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Structure and conserved RNA binding of the PAZ domain

21 January 2018

1 reference

Single processing center models for human Dicer and bacterial RNase III

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors

21 January 2018

1 reference

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NBT1052

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7 April 2018

PubMed ID

15619616

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7 April 2018