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Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus.
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stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
title
Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
main subject
oncolytic virus
1 reference
based on heuristic
inferred from title
Adenoviridae
1 reference
based on heuristic
inferred from title
author
Harald Sauthoff
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
John G Hay
series ordinal
7
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
author name string
Jin Cheng
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
YaoQi Huang
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
David I Kutler
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
Sofia Bajwa
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
William N Rom
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
publication date
24 July 2007
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
published in
Molecular Therapy
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
volume
15
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
issue
11
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
page(s)
1982-1990
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
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The end of the beginning: oncolytic virotherapy achieves clinical proof-of-concept
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Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points
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The oncolytic virotherapy treatment platform for cancer: unique biological and biosafety points to consider
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7 January 2021
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Recent progress in the battle between oncolytic viruses and tumours
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7 January 2021
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Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect
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Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein
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A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.
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Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas
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Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?
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New insights into the role of extracellular matrix during tumor onset and progression.
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Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
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7 January 2021
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Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase
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Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling
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Oncolytic virotherapy: approaches to tumor targeting and enhancing antitumor effects
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Pharmacokinetics of oncolytic measles virotherapy: eventual equilibrium between virus and tumor in an ovarian cancer xenograft model
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Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression
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Effect of hypoxia on Ad5 infection, transgene expression and replication.
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Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy
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Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen
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Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.
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Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion
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Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity
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Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy
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Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation
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Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.
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Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model
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Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression
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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.
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Selective intratumoral amplification of an antiangiogenic vector by an oncolytic virus produces enhanced antivascular and anti-tumor efficacy
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Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector
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Crossref
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7 January 2021
based on heuristic
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Identifiers
DOI
10.1038/SJ.MT.6300264
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
PubMed ID
17653103
1 reference
stated in
Europe PubMed Central
PubMed ID
17653103
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17653103%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
ResearchGate publication ID
6185908
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