(Q40105885)

17 September 2017

The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase (English)

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17 September 2017

6

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17 September 2017

Roya M Dayam

1

1 reference

17 September 2017

Chun X Sun

2

1 reference

17 September 2017

Christopher H Choy

3

1 reference

17 September 2017

Gemma Mancuso

4

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17 September 2017

Michael Glogauer

5

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17 September 2017

language of work or name

English

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publication date

4 August 2017

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17 September 2017

Journal of Immunology

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17 September 2017

199

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17 September 2017

6

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17 September 2017

2096-2105

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Phagosome dynamics during phagocytosis by neutrophils

17 September 2017

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The multifaceted functions of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phagocytosis by neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Granule protein processing and regulated secretion in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Kinetics of fusion of the cytoplasmic granules with phagocytic vacuoles in human polymorphonuclear leukocytes. Biochemical and morphological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The multifaceted role of PIP2 in leukocyte biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphoinositides: tiny lipids with giant impact on cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphoinositides in cell regulation and membrane dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Membrane phospholipid metabolism during phagocytosis in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve regulation of endosome-linked pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantifying Phagocytosis by Immunofluorescence and Microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantitative Immunofluorescence to Study Phagosome Maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Lysosome-related organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PIKfyve negatively regulates exocytosis in neurosecretory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Membrane repair: Ca(2+)-elicited lysosomal exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

The role of Rac1 and Rac2 in bacterial killing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac2 is critical for neutrophil primary granule exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Regulation of innate immunity by Rho GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

P-Rex1 regulates neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

ATF3 is a novel regulator of mouse neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

A targeted mass spectrometric analysis of phosphatidylinositol phosphate species

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601466

21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1601466

1 reference

17 September 2017

1 reference