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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
scientific article published on 6 June 2007
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
title
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
main subject
AKT serine/threonine kinase 1
1 reference
stated in
GOA release 2020-03-11
identical protein binding
1 reference
stated in
GOA release 2020-03-11
author
Morris J. Birnbaum
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
author name string
Xinghai Li
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
Bobby Monks
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
Qingyuan Ge
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
language of work or name
English
0 references
publication date
6 June 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
published in
Nature
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
volume
447
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
issue
7147
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
page(s)
1012-1016
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
cites work
The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Global and societal implications of the diabetes epidemic
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms linking obesity with cardiovascular disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolic control through the PGC-1 family of transcription coactivators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FoxO proteins in insulin action and metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Advances in protein kinase B signalling: AKTion on multiple fronts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel concepts in insulin regulation of hepatic gluconeogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE05861
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NATURE05861
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
Dimensions Publication ID
1016028710
0 references
PubMed publication ID
17554339
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17554339
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17554339%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
ResearchGate publication ID
6283149
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