Wikidata

(Q21114990)

English

AKT serine/threonine kinase 1

mammalian protein found in Homo sapiens

  • PKB
  • proto-oncogene c-Akt
  • protein kinase B alpha
  • v-akt murine thymoma viral oncogene homolog 1
  • RAC-alpha serine/threonine-protein kinase
  • RAC-PK-alpha
  • serine-threonine protein kinase
  • AKT1
  • AKT1m
  • Protein kinase B
  • v-akt murine thymoma viral oncogene-like protein 1
  • PKB alpha
  • rac protein kinase alpha
  • Proto-Oncogene Proteins c-akt
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
74 references
retrieved
8 April 2019
stated in
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
COMMD1 downregulates the epithelial sodium channel through Nedd4-2
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The protooncogene TCL1 is an Akt kinase coactivator
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt/PKB regulates actin organization and cell motility via Girdin/APE
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vimentin is a novel AKT1 target mediating motility and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence for the involvement of FAM110C protein in cell spreading and migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of human myoblast differentiation by PEBP4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bimodal regulation of FoxO3 by AKT and 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of protein kinase B to the plakin family member periplakin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Visualization of biochemical networks in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
A beta-arrestin 2 signaling complex mediates lithium action on behavior
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Charting the molecular links between driver and susceptibility genes in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Akt and CHIP coregulate tau degradation through coordinated interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IEA
EXP
IDA
TAS
13 references
retrieved
1 January 2018
stated in
Akt1 and Akt2: differentiating the aktion
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
1 January 2018
stated in
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
1 January 2018
stated in
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
The protooncogene TCL1 is an Akt kinase coactivator
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
Kinetic mechanism of AKT/PKB enzyme family
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
Akt/PKB regulates actin organization and cell motility via Girdin/APE
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
1 January 2018
stated in
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P31749&geneProductId=UniProtKB:P31749
determination method or standard
EXP
protein serine/threonine kinase activity
determination method or standard
EXP
IBA
IDA
IEA
NAS
TAS
15 references
retrieved
8 April 2019
stated in
Akt1 and Akt2: differentiating the aktion
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
The protooncogene TCL1 is an Akt kinase coactivator
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Akt/PKB regulates actin organization and cell motility via Girdin/APE
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Kinetic mechanism of AKT/PKB enzyme family
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IBA
retrieved
8 April 2019
stated in
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
EXP
cell component
cytoplasm
determination method or standard
IDA
ISS
IEA
TAS
6 references
retrieved
8 April 2019
stated in
Akt1 and Akt2: differentiating the aktion
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
plasma membrane
determination method or standard
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
Akt1 and Akt2: differentiating the aktion
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IEA
retrieved
8 April 2019
stated in
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt
GOA
curator
UniProt
UniProt protein ID
P31749
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
retrieved
8 April 2019
stated in
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749
determination method or standard
IDA
biological process

Identifiers

MeSH descriptor ID
D051057
subject named as
Proto-Oncogene Proteins c-akt
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21114990&oldid=2249561570"