(Q42152316)

17 October 2017

title

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation (English)

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17 October 2017

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8

Ruth Nussinov

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17 October 2017

7

Wenkang Huang

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17 October 2017

6

Qiancheng Shen

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17 October 2017

Shaoyong Lu

1

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17 October 2017

Rong Deng

2

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17 October 2017

Haiming Jiang

3

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17 October 2017

Huili Song

4

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17 October 2017

Shuai Li

5

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17 October 2017

Jianxiu Yu

9

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17 October 2017

Jian Zhang

10

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17 October 2017

publication date

4 August 2015

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17 October 2017

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17 October 2017

volume

23

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17 October 2017

issue

9

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17 October 2017

page(s)

1725-1734

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describes a project that uses

17 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7734571/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

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12 December 2020

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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12 December 2020

The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase

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12 December 2020

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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12 December 2020

Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

1 reference

12 December 2020

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

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12 December 2020

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

1 reference

12 December 2020

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1 reference

12 December 2020

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

1 reference

12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

12 December 2020

Recent advances in the protein kinase B signaling pathway

1 reference

12 December 2020

H++: a server for estimating pKas and adding missing hydrogens to macromolecules

1 reference

12 December 2020

The Amber biomolecular simulation programs

1 reference

12 December 2020

Markov propagation of allosteric effects in biomolecular systems: application to GroEL-GroES.

1 reference

12 December 2020

AKT/PKB signaling: navigating downstream

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12 December 2020

Dynamic personalities of proteins

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12 December 2020

An Allosteric Circuit in Caspase-1

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12 December 2020

Allosteric regulation and catalysis emerge via a common route.

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12 December 2020

Ligand mapping on protein surfaces by the 3D-RISM theory: toward computational fragment-based drug design

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12 December 2020

The origin of allosteric functional modulation: multiple pre-existing pathways

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12 December 2020

Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic

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12 December 2020

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion

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12 December 2020

Physiological regulation of Akt activity and stability.

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12 December 2020

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

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12 December 2020

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

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12 December 2020

Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

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12 December 2020

Accessing a hidden conformation of the maltose binding protein using accelerated molecular dynamics

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12 December 2020

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

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12 December 2020

Placevent: an algorithm for prediction of explicit solvent atom distribution-application to HIV-1 protease and F-ATP synthase.

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12 December 2020

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12 December 2020

An ATP-site on-off switch that restricts phosphatase accessibility of Akt

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12 December 2020

The methionine-aromatic motif plays a unique role in stabilizing protein structure

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12 December 2020

Allosteric post-translational modification codes

1 reference

12 December 2020

NetworkView: 3D display and analysis of protein·RNA interaction networks

1 reference

12 December 2020

AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.

1 reference

12 December 2020

Allostery in disease and in drug discovery

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12 December 2020

ASD v2.0: updated content and novel features focusing on allosteric regulation

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12 December 2020

Structural basis of AMPK regulation by small molecule activators

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12 December 2020

Lytic water dynamics reveal evolutionarily conserved mechanisms of ATP hydrolysis by TIP49 AAA+ ATPases.

1 reference

12 December 2020

Harnessing allostery: a novel approach to drug discovery

1 reference

12 December 2020

Recent computational advances in the identification of allosteric sites in proteins

1 reference

12 December 2020

The design of covalent allosteric drugs

1 reference

12 December 2020

The structural basis of ATP as an allosteric modulator

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12 December 2020

Two pathways mediate interdomain allosteric regulation in pin1

1 reference

12 December 2020

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

1 reference

12 December 2020

10.1016/J.STR.2015.06.027

Identifiers

DOI

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17 October 2017

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