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Physiological regulation of Akt activity and stability.
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Europe PubMed Central
PMCID
2826820
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
review article
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Europe PubMed Central
title
Physiological regulation of Akt activity and stability
(English)
1 reference
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Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
author
Mien-Chie Hung
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2
object named as
Mien-Chie Hung
1 reference
stated in
Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
author name string
Yong Liao
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1
1 reference
stated in
Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
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18 January 2020
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English
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1 January 2010
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Europe PubMed Central
PMCID
2826820
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
published in
American Journal of Translational Research
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Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
volume
2
1 reference
stated in
Europe PubMed Central
PMCID
2826820
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
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19-42
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Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
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18 January 2020
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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
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Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
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21 June 2018
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21 June 2018
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond
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21 June 2018
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21 June 2018
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint
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21 June 2018
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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21 June 2018
Oncogenic PI3K deregulates transcription and translation
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21 June 2018
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21 June 2018
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21 June 2018
SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation
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21 June 2018
Perturbations of the AKT signaling pathway in human cancer
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21 June 2018
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21 June 2018
The Akt-mTOR tango and its relevance to cancer
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21 June 2018
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21 June 2018
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
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21 June 2018
An expanding role for mTOR in cancer
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21 June 2018
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
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21 June 2018
Regulation of the p73 protein stability and degradation
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21 June 2018
Activated Akt expression in breast cancer: correlation with p53, Hdm2 and patient outcome.
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21 June 2018
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
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21 June 2018
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update
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21 June 2018
Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt.
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21 June 2018
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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21 June 2018
PP2A: the expected tumor suppressor
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21 June 2018
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
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21 June 2018
Regulated association of protein kinase B/Akt with breast tumor kinase
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21 June 2018
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein
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21 June 2018
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes
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21 June 2018
A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells
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21 June 2018
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
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21 June 2018
PDK1, the master regulator of AGC kinase signal transduction
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21 June 2018
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
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21 June 2018
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21 June 2018
Pinning down cell signaling, cancer and Alzheimer's disease
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21 June 2018
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
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21 June 2018
Physiological functions of protein kinase B/Akt
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21 June 2018
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21 June 2018
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21 June 2018
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
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21 June 2018
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
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21 June 2018
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
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21 June 2018
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21 June 2018
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21 June 2018
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
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21 June 2018
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21 June 2018
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21 June 2018
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21 June 2018
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retrieved
21 June 2018
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
Function of WW domains as phosphoserine- or phosphothreonine-binding modules
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
Alterations of the PPP2R1B gene in human lung and colon cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
Akt activation by growth factors is a multiple-step process: the role of the PH domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
Mechanism of activation of protein kinase B by insulin and IGF-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
A target for phosphoinositide 3-kinase: Akt/PKB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
21 June 2018
New insights into mTOR signaling: mTORC2 and beyond
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
PIN1, the cell cycle and cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
PIN1 gene overexpression and beta-catenin gene mutation/expression in hepatocellular carcinoma and their significance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
mTORC2 Caught in a SINful Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
AKT signaling in normal and malignant cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Regulation of p53: intricate loops and delicate balances
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826820
retrieved
30 October 2018
PHLPPing it off: phosphatases get in the Akt
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Heat shock protein inhibitors and vaccines as new agents in cancer treatment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20182580
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
PMCID
2826820
1 reference
stated in
Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
PubMed ID
20182580
1 reference
stated in
Europe PubMed Central
PMCID
2826820
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20182580%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
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