(Q44830447)

6 December 2017

Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells (English)

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6 December 2017

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Oliver Riesterer

1

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6 December 2017

Daniel Zingg

2

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6 December 2017

Jörg Hummerjohann

3

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6 December 2017

Stephan Bodis

4

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6 December 2017

Martin Pruschy

5

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6 December 2017

language of work or name

English

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publication date

1 June 2004

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6 December 2017

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6 December 2017

23

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6 December 2017

4624-4635

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6 December 2017

26

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207596

6 December 2017

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cites work

Mechanism of activation and function of protein kinase B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Prognostic significance of angiogenesis in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Drug inhibition of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Therapies directed at vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

The role of Asp-462 in regulating Akt activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Angiogenesis in cancer and other diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

A novel method for real time quantitative RT-PCR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Real time quantitative PCR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Tumor angiogenesis as a therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Mechanisms and future directions for angiogenesis-based cancer therapies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Prognostic value of vascular endothelial growth factor and its receptors Flt-1 and Flk-1 in astrocytic tumours.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207596

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207596

1 reference

Dimensions Publication ID

6 December 2017

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1 reference