(Q35163966)

6 August 2017

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title

Unravelling the activation mechanisms of protein kinase B/Akt (English)

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6 August 2017

James R Woodgett

2

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author name string

Michael P Scheid

series ordinal

1

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6 August 2017

language of work or name

English

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publication date

1 July 2003

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6 August 2017

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6 August 2017

volume

546

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6 August 2017

issue

1

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6 August 2017

page(s)

108-112

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Cellular survival: a play in three Akts

6 August 2017

cites work

1 reference

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PKB/AKT: functional insights from genetic models

7 January 2021

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

7 January 2021

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High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

7 January 2021

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

7 January 2021

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

7 January 2021

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

7 January 2021

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The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

7 January 2021

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A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

7 January 2021

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

7 January 2021

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

7 January 2021

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

7 January 2021

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

7 January 2021

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

7 January 2021

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Snapping of the carboxyl terminal tail of the catalytic subunit of PKA onto its core: characterization of the sites by mutagenesis

7 January 2021

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Mechanism of activation of protein kinase B by insulin and IGF-1

7 January 2021

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 January 2021

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

7 January 2021

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Cellular signaling: pivoting around PDK-1.

7 January 2021

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

7 January 2021

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Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

7 January 2021

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

7 January 2021

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

7 January 2021

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

7 January 2021

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Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

7 January 2021

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Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

7 January 2021

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

7 January 2021

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Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

7 January 2021

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

7 January 2021

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Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

7 January 2021

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 January 2021

1 reference

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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

7 January 2021

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Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

7 January 2021

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Regulation of Akt/PKB activation by tyrosine phosphorylation

7 January 2021

1 reference

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Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

7 January 2021

1 reference

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Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

7 January 2021

1 reference

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The protooncogene TCL1 is an Akt kinase coactivator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900562-3

Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1

7 January 2021

1 reference

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10.1016/S0014-5793(03)00562-3

7 January 2021

Identifiers

DOI

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6 August 2017

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