(Q36337966)

13 August 2017

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title

Oncogenic PI3K deregulates transcription and translation (English)

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13 August 2017

Peter K Vogt

4

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Li Zhao

series ordinal

3

object named as

Li Zhao

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13 August 2017

Andreas G Bader

1

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13 August 2017

Sohye Kang

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 December 2005

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13 August 2017

published in

Nature Reviews Cancer

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13 August 2017

volume

5

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13 August 2017

issue

12

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13 August 2017

page(s)

921-929

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https://scigraph.springernature.com/pub.10.1038/nrc1753

13 August 2017

exact match

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cites work

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

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21 January 2018

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Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways

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Mutated PI 3-kinases: cancer targets on a silver platter.

21 January 2018

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

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High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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The PIK3CA gene is mutated with high frequency in human breast cancers.

31 March 2020

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Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

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Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

31 March 2020

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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

31 March 2020

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Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

31 March 2020

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Mutations of PIK3CA in gastric adenocarcinoma

31 March 2020

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

31 March 2020

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PIK3CA mutations in advanced ovarian carcinomas

31 March 2020

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PIK3CA mutations in glioblastoma multiforme.

31 March 2020

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Signaling by distinct classes of phosphoinositide 3-kinases

31 March 2020

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The phosphoinositide 3-kinase pathway

31 March 2020

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PI3K in lymphocyte development, differentiation and activation

31 March 2020

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Phosphoinositide 3-kinase signalling--which way to target?

31 March 2020

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

31 March 2020

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

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Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

31 March 2020

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

31 March 2020

1 reference

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

31 March 2020

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

31 March 2020

1 reference

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

31 March 2020

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease

31 March 2020

1 reference

PTEN and myotubularin: novel phosphoinositide phosphatases

31 March 2020

1 reference

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

1 reference

PTEN: one gene, many syndromes

31 March 2020

1 reference

PTEN function: how normal cells control it and tumour cells lose it

31 March 2020

1 reference

PTEN: life as a tumor suppressor

31 March 2020

1 reference

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

31 March 2020

1 reference

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

31 March 2020

1 reference

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

31 March 2020

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The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

31 March 2020

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The akt kinase: molecular determinants of oncogenicity

31 March 2020

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An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme

31 March 2020

1 reference

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

31 March 2020

1 reference

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

1 reference

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

31 March 2020

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

31 March 2020

1 reference

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

31 March 2020

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Direct control of the Forkhead transcription factor AFX by protein kinase B

31 March 2020

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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

31 March 2020

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Negative regulation of the forkhead transcription factor FKHR by Akt.

31 March 2020

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Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

31 March 2020

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

31 March 2020

1 reference

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

31 March 2020

1 reference

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

31 March 2020

1 reference

Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.

31 March 2020

1 reference

The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription

31 March 2020

1 reference

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

31 March 2020

1 reference

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

31 March 2020

1 reference

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

31 March 2020

1 reference

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

31 March 2020

1 reference

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

31 March 2020

1 reference

Nuclear factor-kappaB: the enemy within

31 March 2020

1 reference

NF-kappaB in cancer: from innocent bystander to major culprit

31 March 2020

1 reference

Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

31 March 2020

1 reference

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

31 March 2020

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

31 March 2020

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Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

31 March 2020

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

31 March 2020

1 reference

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

31 March 2020

1 reference

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

31 March 2020

1 reference

Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer

31 March 2020

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Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

31 March 2020

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Suppression of PTEN expression by NF-kappa B prevents apoptosis

31 March 2020

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Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

31 March 2020

1 reference

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

1 reference

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

31 March 2020

1 reference

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

31 March 2020

1 reference

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

31 March 2020

1 reference

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

31 March 2020

1 reference

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

1 reference

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

31 March 2020

1 reference

Immunophilins: beyond immunosuppression

31 March 2020

1 reference

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

31 March 2020

1 reference

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

31 March 2020

1 reference

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

31 March 2020

1 reference

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

31 March 2020

1 reference

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

31 March 2020

1 reference

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

31 March 2020

1 reference

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

31 March 2020

1 reference

TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.

31 March 2020

1 reference

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

31 March 2020

1 reference

Modulation of transcription of rRNA genes by rapamycin

31 March 2020

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Upstream and downstream of mTOR

31 March 2020

1 reference

Drosophila S6 kinase: a regulator of cell size

31 March 2020

1 reference

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

31 March 2020

1 reference

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

31 March 2020

1 reference

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

31 March 2020

1 reference

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

31 March 2020

1 reference

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

31 March 2020

1 reference

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

31 March 2020

1 reference

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

31 March 2020

1 reference

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

31 March 2020

1 reference

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

31 March 2020

1 reference

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

31 March 2020

1 reference

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

1 reference

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

31 March 2020

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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

31 March 2020

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Identification of a conserved motif required for mTOR signaling

31 March 2020

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

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Role of cytoplasmic mRNP proteins in translation

31 March 2020

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Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition

31 March 2020

1 reference

Translational regulation by Y-box transcription factor: involvement of the major mRNA-associated protein, p50.

31 March 2020

1 reference

The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage

31 March 2020

1 reference

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

31 March 2020

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Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation

31 March 2020

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Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock

31 March 2020

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Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

31 March 2020

1 reference

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

31 March 2020

1 reference

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs

31 March 2020

1 reference

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

31 March 2020

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Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

31 March 2020

1 reference

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

1 reference

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

1 reference

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

31 March 2020

1 reference

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

31 March 2020

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

31 March 2020

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

31 March 2020

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PIK3CA is implicated as an oncogene in ovarian cancer.

31 March 2020

1 reference

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

31 March 2020

1 reference

Structural insights into phosphoinositide 3-kinase catalysis and signalling

31 March 2020

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

31 March 2020

1 reference

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

31 March 2020

1 reference

Erlotinib in lung cancer - molecular and clinical predictors of outcome

31 March 2020

1 reference

In situ click chemistry: enzyme inhibitors made to their own specifications

31 March 2020

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In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

31 March 2020

1 reference

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

31 March 2020

1 reference

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

31 March 2020

1 reference

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

31 March 2020

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Rheb binds and regulates the mTOR kinase

31 March 2020

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

31 March 2020

1 reference

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

31 March 2020

1 reference

Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression

31 March 2020

1 reference

Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma

31 March 2020

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PIK3CA as an oncogene in cervical cancer

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

31 March 2020

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Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

31 March 2020

1 reference

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1753

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13 August 2017

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