(Q40615729)

English

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

scientific article published on 17 November 2003

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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Sunghoon Kim

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Claire Domon-Dell

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Junghee Kang

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Dai H Chung

4

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21 December 2019

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17 November 2003

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21 December 2019

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7

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Journal of Biological Chemistry

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21 December 2019

279

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21 December 2019

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21 December 2019

4285-4291

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21 December 2019

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Activation of PPARgamma increases PTEN expression in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Possible new role for NF-kappaB in the resolution of inflammation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

The significance of DNA and protein adducts in human biomonitoring studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Induced stabilization of IκBα can facilitate its re‐synthesis and prevent sequential degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308383200

21 January 2018

Identifiers

10.1074/JBC.M308383200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14623898%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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