(Q36429460)

14 August 2017

1 reference

title

Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond (English)

1 reference

14 August 2017

Georgios V Georgakis

1

1 reference

PubMed ID

16555999

14 August 2017

Anas Younes

series ordinal

2

1 reference

PubMed ID

16555999

14 August 2017

language of work or name

English

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publication date

1 April 2005

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14 August 2017

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14 August 2017

1

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14 August 2017

2

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14 August 2017

273-281

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A new puffing pattern induced by temperature shock and DNP in drosophila

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Discovery of the heat shock response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Between genotype and phenotype: protein chaperones and evolvability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The glucose-regulated protein grp94 is related to heat shock protein hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

GRP94, an ER chaperone with protein and peptide binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Comparison of the carboxy-terminal DP-repeat region in the co-chaperones Hop and Hip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Heat shock proteins in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

HSP27 and HSP70: potentially oncogenic apoptosis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Manipulating heat shock protein expression in laboratory animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Therapeutic and diagnostic implications of Hsp90 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 isoforms: functions, expression and clinical importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The charged region of Hsp90 modulates the function of the N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The C-terminal half of Hsp90 is responsible for its cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hop modulates Hsp70/Hsp90 interactions in protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hop: more than an Hsp70/Hsp90 adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90: the vulnerable chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Reduced levels of hsp90 compromise steroid receptor action in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 activation and cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Altered states: selectively drugging the Hsp90 cancer chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Overview: Translating Hsp90 Biology into Hsp90 Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Natural Product Origins of Hsp90 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The Hsp90 chaperone complex as a novel target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

21 January 2018

Heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Concise asymmetric syntheses of radicicol and monocillin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 as a therapeutic target in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Regulation of survivin function by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Heat-shock proteins as regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

21 January 2018

Putting the rap on Akt.

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

Genetic interactions between Hsp90 and the Cdc2 mitotic machineryin the fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14796694.1.2.273

21 January 2018

Identifiers

DOI

10.1517/14796694.1.2.273

1 reference

14 August 2017

1 reference

PubMed ID

16555999