(Q35791991)

10 August 2017

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title

Therapeutic and diagnostic implications of Hsp90 activation (English)

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10 August 2017

Adeela Kamal

1

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PubMed ID

15177193

10 August 2017

Marcus F Boehm

series ordinal

2

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PubMed ID

15177193

10 August 2017

Francis J Burrows

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3

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10 August 2017

1 June 2004

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Trends in Molecular Medicine

10 August 2017

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10 August 2017

10

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10 August 2017

283-290

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10 August 2017

6

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The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

10 August 2017

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12 December 2020

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

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12 December 2020

Stimulation of the weak ATPase activity of human hsp90 by a client protein

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12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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12 December 2020

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

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12 December 2020

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

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12 December 2020

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

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12 December 2020

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

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12 December 2020

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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12 December 2020

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins

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12 December 2020

Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro

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12 December 2020

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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12 December 2020

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

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12 December 2020

Differential expression of heat shock proteins in pancreatic carcinoma

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12 December 2020

Reconstitution of progesterone receptor with heat shock proteins

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12 December 2020

Stress management - heat shock protein-70 and the regulation of apoptosis

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12 December 2020

Geldanamycin provides posttreatment protection against glutamate-induced oxidative toxicity in a mouse hippocampal cell line

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12 December 2020

Physiologically-Based Pharmacokinetics and Molecular Pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and Its Active Metabolite in Tumor-Bearing Mice

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12 December 2020

Immunosuppressive effects of the heat shock protein 90-binding antibiotic geldanamycin

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12 December 2020

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

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12 December 2020

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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12 December 2020

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

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12 December 2020

The assembly of progesterone receptor-hsp90 complexes using purified proteins

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12 December 2020

Host cell factor requirement for hepatitis C virus enzyme maturation

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12 December 2020

FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.

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12 December 2020

Selective over-expression of mRNA coding for 90 KDa stress-protein in human ovarian cancer

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12 December 2020

Heat shock protein-90, IL-6 and IL-10 in bladder cancer

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12 December 2020

Hsp90 as a capacitor for morphological evolution

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12 December 2020

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

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12 December 2020

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

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12 December 2020

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

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12 December 2020

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

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12 December 2020

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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12 December 2020

Radicicol-sensitive peptide binding to the N-terminal portion of GRP94

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12 December 2020

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

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12 December 2020

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

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12 December 2020

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol

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12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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12 December 2020

Unusual expression and localization of heat-shock proteins in human tumor cells

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12 December 2020

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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12 December 2020

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

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12 December 2020

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12 December 2020

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

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12 December 2020

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

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12 December 2020

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

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12 December 2020

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

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12 December 2020

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

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12 December 2020

Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes

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12 December 2020

ATPases as drug targets: learning from their structure

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12 December 2020

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

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12 December 2020

Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia

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12 December 2020

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

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12 December 2020

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase

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12 December 2020

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

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12 December 2020

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

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12 December 2020

Quantitative immunohistochemical evaluation of HER2/neu expression with HercepTestTM in breast carcinoma by image analysis.

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12 December 2020

Cancer: the rules of attraction

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12 December 2020

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures

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12 December 2020

Expression and roles of heat shock proteins in human breast cancer.

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12 December 2020

ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin

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12 December 2020

Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts

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12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

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12 December 2020

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

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12 December 2020

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

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12 December 2020

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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12 December 2020

Heat shock protein 90 as a molecular target for cancer therapeutics

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12 December 2020

Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases

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12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

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12 December 2020

10.1016/J.MOLMED.2004.04.006

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15177193