(Q31108274)

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Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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Europe PubMed Central

PubMed publication ID

28 June 2017

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Gabriela Chiosis

1

object named as

Gabriela Chiosis

0 references

Alexander A. Shtil

object named as

Alexander Shtil

3

1 reference

ORCID Public Data File 2021

author name string

Brian Lucas

2

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Henri Huezo

4

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Neal Rosen

5

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

language of work or name

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publication date

1 November 2002

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

28 June 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

3555-3564

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Hsp90 as a capacitor for morphological evolution

1 reference

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The Hsp90 complex--a super-chaperone machine as a novel drug target

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 & Co. - a holding for folding

1 reference

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7 January 2021

based on heuristic

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Recent Advances in the Study of hsp90 Structure and Mechanism of Action

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The glucose-regulated protein grp94 is related to heat shock protein hsp90.

1 reference

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7 January 2021

based on heuristic

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The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties

1 reference

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7 January 2021

based on heuristic

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

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based on heuristic

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

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based on heuristic

inferred from DOI database lookup

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

1 reference

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based on heuristic

inferred from DOI database lookup

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

1 reference

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based on heuristic

inferred from DOI database lookup

Stereospecific antitumor activity of radicicol oxime derivatives

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Simple Method of Calculating Octanol/Water Partition Coefficient

1 reference

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based on heuristic

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900253-5

7 January 2021

based on heuristic

inferred from DOI database lookup

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

1 reference

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In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/S0968-0896(02)00253-5

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

release_rcazfnhzqjdpzif5h676mu2l5u

1 reference

https://api.fatcat.wiki/v0/release/rcazfnhzqjdpzif5h676mu2l5u

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

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