(Q37416799)

20 August 2017

1 reference

title

Induction of Akt activity by chemotherapy confers acquired resistance (English)

1 reference

20 August 2017

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2

Mien-Chie Hung

1 reference

20 August 2017

Wei-Chien Huang

1

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20 August 2017

publication date

1 March 2009

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Journal of the Formosan Medical Association

20 August 2017

published in

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20 August 2017

volume

108

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20 August 2017

issue

3

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20 August 2017

page(s)

180-194

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Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

20 August 2017

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Role of translocation in the activation and function of protein kinase B

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7 January 2021

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

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7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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7 January 2021

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

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7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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7 January 2021

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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7 January 2021

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

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7 January 2021

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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7 January 2021

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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7 January 2021

Structure, regulation and function of PKB/AKT--a major therapeutic target

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7 January 2021

The protein kinase B/Akt signalling pathway in human malignancy

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7 January 2021

The activation of Akt/PKB signaling pathway and cell survival.

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PI3K/PTEN signaling in tumorigenesis and angiogenesis

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Exploiting the PI3K/AKT pathway for cancer drug discovery

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mutation of the PIK3CA gene in ovarian and breast cancer

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7 January 2021

PIK3CA mutations in ovarian cancer.

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7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

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https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Patterns ofPIK3CA alterations in familial colorectal and endometrial carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Alternate molecular genetic pathways in ovarian carcinomas of common histological types.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Somatic mutation and gain of copy number of PIK3CA in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Current overview of the role of Akt in cancer studies via applied immunohistochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Increased expression of pAKT is associated with radiation resistance in cervical cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Activation of PI3K/Akt signaling and hormone resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt expression may predict favorable prognosis in cholangiocarcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Control of EGF receptor signaling by clathrin-mediated endocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

The chemotherapeutic agent VP16 increases the stability of HB-EGF mRNA by a mechanism involving the 3'-UTR.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Inhibition of the epidermal growth factor receptor in bladder cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Urokinase system expression in gastric carcinoma: prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non-small cell lung cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Role of IkappaB kinase in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

A p34(cdc2) survival checkpoint in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Phosphorylation of HDM2 by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

PI-3' kinase and NF-kappaB cross-signaling in human pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Gas6 anti-apoptotic signaling requires NF-kappa B activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Altering protein turnover in tumor cells: new opportunities for anti-cancer therapies

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

mTOR and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

A new fork for clinical application: targeting forkhead transcription factors in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0929-6646%2809%2960051-6

7 January 2021

10.1016/S0929-6646(09)60051-6

Identifiers

DOI

1 reference

20 August 2017

1 reference