(Q34124356)

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Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling

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Europe PubMed Central

PubMed publication ID

31 July 2017

Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Yen-Chiu Lin-Lee

4

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Yen-chiu Lin-Lee

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Europe PubMed Central

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31 July 2017

Gordon B. Mills

6

object named as

Gordon B Mills

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Europe PubMed Central

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31 July 2017

author name string

Macus Tien Kuo

1

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31 July 2017

Zesheng Liu

2

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31 July 2017

Yingjie Wei

3

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31 July 2017

Shigeru Tatebe

5

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31 July 2017

Hitoshi Unate

7

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31 July 2017

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1 March 2002

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31 July 2017

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31 July 2017

21

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31 July 2017

13

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Europe PubMed Central

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31 July 2017

1945-1954

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Europe PubMed Central

PubMed publication ID

31 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205117

0 references

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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Ras and Rho GTPases: a family reunion

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Rho GTPases and their effector proteins

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Multidrug resistant proteins

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Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.

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Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

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Kinase regulation in inflammatory response

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2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway

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Using structure to define the function of phosphoinositide 3-kinase family members

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Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas

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PI3K: downstream AKTion blocks apoptosis

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PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.

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Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1.

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

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Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.

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A Rac1 effector site controlling mitogenesis through superoxide production

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Induction of NF-kappaB by the Akt/PKB kinase

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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

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Multidrug resistance: molecular mechanisms and clinical relevance

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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response

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Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line

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Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region

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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

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Comparison between DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene.

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Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

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Cell signaling by receptor tyrosine kinases

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Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

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Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas

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Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis.

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Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

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Phosphoinositide 3-kinases: a conserved family of signal transducers

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2-Acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation

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Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

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PTEN/MMAC1 mutations in hepatocellular carcinomas

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Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

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NF-κB-mediated Induction ofmdr1bExpression by Insulin in Rat Hepatoma Cells

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Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase

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10.1038/SJ.ONC.1205117

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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