(Q28268516)

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mTOR and cancer therapy

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Europe PubMed Central

mTOR and cancer therapy (English)

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J B Easton

1

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P J Houghton

2

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16 October 2006

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25

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48

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6436-46

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

1 reference

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21 January 2018

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

1 reference

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21 January 2018

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

1 reference

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21 January 2018

The TOR pathway: a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

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21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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21 January 2018

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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21 January 2018

Clinical development of mammalian target of rapamycin inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma

1 reference

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21 January 2018

Increased risk of cancer in the Peutz-Jeghers syndrome

1 reference

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21 January 2018

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Progression of eIF4e gene amplification and overexpression in benign and malignant tumors of the head and neck.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Role of VHL gene mutation in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Development by self-digestion: molecular mechanisms and biological functions of autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

PIK3CA mutations in breast cancer are associated with poor outcome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Hypoxia-induced energy stress regulates mRNA translation and cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells

1 reference

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21 January 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

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21 January 2018

Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma

1 reference

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21 January 2018

Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells

1 reference

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21 January 2018

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1 reference

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21 January 2018

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Myc: a weapon of mass destruction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Cancer. Addiction to oncogenes--the Achilles heal of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Elongation factor-2 kinase regulates autophagy in human glioblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

21 January 2018

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

7 January 2021

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Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

7 January 2021

based on heuristic

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4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

7 January 2021

based on heuristic

inferred from DOI database lookup

Pattern of amplification and overexpression of the eukaryotic initiation factor 4E gene in solid tumor

1 reference

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7 January 2021

based on heuristic

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Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209886

7 January 2021

based on heuristic

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