(Q24548951)

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Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

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20 January 2020

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells (English)

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Europe PubMed Central

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20 January 2020

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Eileen Connolly

1

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20 January 2020

Robert J Schneider

4

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20 January 2020

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Steve Braunstein

2

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20 January 2020

Silvia Formenti

3

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20 January 2020

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1 May 2006

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20 January 2020

Molecular and Cellular Biology

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20 January 2020

26

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20 January 2020

3955-3965

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20 January 2020

10

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20 January 2020

Regulation of mTOR and cell growth in response to energy stress by REDD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Breast cancer cell lines: friend or foe?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

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24 March 2017

Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes

1 reference

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24 March 2017

Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA

1 reference

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24 March 2017

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

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24 March 2017

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

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7 April 2017

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

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24 March 2017

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

1 reference

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24 March 2017

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Upstream and downstream of mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

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24 March 2017

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

24 March 2017

Molecular mechanisms of translation initiation in eukaryotes

1 reference

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7 April 2017

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

1 reference

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7 April 2017

Hypoxia-induced energy stress regulates mRNA translation and cell growth

1 reference

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27 September 2017

Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase

1 reference

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27 September 2017

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

1 reference

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27 September 2017

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

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27 September 2017

REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

27 September 2017

Activating transcription factor 4 is translationally regulated by hypoxic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

27 September 2017

The multifaceted role of mTOR in cellular stress responses

1 reference

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27 September 2017

Regulation of transcription and translation by hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

27 September 2017

Hypoxic gene expression and metastasis

1 reference

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27 September 2017

The role of translation in neoplastic transformation from a pathologist's point of view

1 reference

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27 September 2017

Targets and mechanisms for the regulation of translation in malignant transformation

1 reference

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27 September 2017

Targeting hypoxia tolerance in cancer

1 reference

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27 September 2017

Crosstalk between angiogenesis and lymphangiogenesis in tumor progression

1 reference

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27 September 2017

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489005

27 September 2017

Regulation of peptide-chain elongation in mammalian cells

1 reference

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27 September 2017

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

1 reference

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27 September 2017

Mechanism, origin, and evolution of anoxia tolerance in animals

1 reference

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27 September 2017

Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle

1 reference

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27 September 2017

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

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27 September 2017

Profile of genetic alterations and tumorigenicity of human breast cancer cells.

1 reference

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27 September 2017

Translational control of growth factor and proto-oncogene expression

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27 September 2017

Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia

1 reference

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27 September 2017

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

1 reference

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27 September 2017

Translational regulation of XIAP expression and cell survival during hypoxia in human cholangiocarcinoma

1 reference

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28 November 2018

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

1 reference

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28 November 2018

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

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28 November 2018

Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

1 reference

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28 November 2018

Identifiers

10.1128/MCB.26.10.3955-3965.2006

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16648488%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16648488%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16648488%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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