(Q22253428)

English

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

scientific article

In more languages

Statements

scholarly article

0 references

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells (English)

0 references

apoptotic process

0 references

0 references

0 references

AKT serine/threonine kinase 1

1 reference

GOA release 2020-03-11

Interleukin 1 beta

1 reference

GOA release 2020-03-11

Interleukin 1 alpha

1 reference

GOA release 2020-03-11

Tumor necrosis factor

1 reference

GOA release 2020-03-11

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

GOA release 2020-03-11

author name string

L A Madge

1

author given names

L A

author last names

Madge

1 reference

28 March 2023

J S Pober

2

author given names

J S

author last names

Pober

1 reference

28 March 2023

language of work or name

0 references

publication date

19 May 2000

0 references

Journal of Biological Chemistry

0 references

275

0 references

20

0 references

15458-65

0 references

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Raf-1 activates MAP kinase-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Two TNF receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

TRAF6 is a signal transducer for interleukin-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Identification and characterization of an IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Rho family GTPases bind to phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

A role for c-Raf kinase and Ha-Ras in cytokine-mediated induction of cell adhesion molecules.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

21 January 2018

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of phosphoinositide-3-OH kinase in Ras signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of phosphatidylinositol 3-kinase and Rac in the nuclear signaling by tumor necrosis factor-alpha in rat-2 fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

The function of cell adhesion molecules in lung inflammation: more questions than answers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001237200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M001237200

0 references

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q22253428&oldid=1863458210"