(Q40127820)

English

The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

scientific article published on 25 May 2007

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scholarly article

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31 December 2019

The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment (English)

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Europe PubMed Central

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31 December 2019

ataxia telangiectasia

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based on heuristic

inferred from title

Alan Yueh-Luen Lee

3

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31 December 2019

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Erin Olson

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31 December 2019

Christian J Nievera

2

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Europe PubMed Central

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31 December 2019

Longchuan Chen

4

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31 December 2019

Xiaohua Wu

5

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31 December 2019

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25 May 2007

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31 December 2019

Journal of Biological Chemistry

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31 December 2019

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31 December 2019

31

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31 December 2019

22939-22952

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31 December 2019

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

In situ visualization of DNA double-strand break repair in human fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The Mre11 complex is required for ATM activation and the G2/M checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Nbs1 is required for ATR-dependent phosphorylation events

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Rad50 depletion impacts upon ATR-dependent DNA damage responses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Telomerase maintains telomere structure in normal human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Chk2 activation dependence on Nbs1 after DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Structural basis for phosphorylation-dependent signaling in the DNA-damage response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Claspin, a regulator of Chk1 in DNA replication stress pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Identification and functional analysis of TopBP1 and its homologs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

ATR-dependent phosphorylation of ATRIP in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702162200

21 January 2018

Identifiers

10.1074/JBC.M702162200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17526493%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17526493%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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