(Q40130350)

17 September 2017

Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia (English)

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17 September 2017

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Yali Dou

1

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PubMed ID

18224408

17 September 2017

Jay L Hess

series ordinal

2

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17 September 2017

4 December 2007

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International Journal of Hematology

17 September 2017

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17 September 2017

87

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17 September 2017

1

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17 September 2017

10-18

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https://scigraph.springernature.com/pub.10.1007/s12185-007-0009-8

17 September 2017

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cites work

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12185-007-0009-8

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12185-007-0009-8

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells

21 January 2018

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12 December 2020

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

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12 December 2020

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

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12 December 2020

Effects of HOX homeobox genes in blood cell differentiation

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12 December 2020

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12 December 2020

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

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12 December 2020

MLL: a histone methyltransferase disrupted in leukemia

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12 December 2020

Gene expression profiling of pediatric acute myelogenous leukemia

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12 December 2020

The bromodomain: a chromatin browser?

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12 December 2020

Molecular pathology of the MEN1 gene

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12 December 2020

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

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12 December 2020

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

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12 December 2020

Definitive hematopoiesis requires the mixed-lineage leukemia gene

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12 December 2020

Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

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12 December 2020

The MLL partial tandem duplication in acute myeloid leukaemia

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12 December 2020

Cyclin-dependent kinase pathways as targets for cancer treatment

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12 December 2020

FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.

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12 December 2020

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

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12 December 2020

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

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12 December 2020

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

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12 December 2020

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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12 December 2020

Expression of HOX genes in acute leukemia cell lines with and without MLL translocations

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12 December 2020

Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

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12 December 2020

MLL targets SET domain methyltransferase activity to Hox gene promoters

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12 December 2020

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

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12 December 2020

The role of HOX homeobox genes in normal and leukemic hematopoiesis

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12 December 2020

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin

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12 December 2020

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

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12 December 2020

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

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12 December 2020

Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

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12 December 2020

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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12 December 2020

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

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12 December 2020

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

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12 December 2020

Common mechanism for oncogenic activation of MLL by forkhead family proteins

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12 December 2020

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

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12 December 2020

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

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12 December 2020

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

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12 December 2020

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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12 December 2020

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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12 December 2020

The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

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12 December 2020

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

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12 December 2020

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

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12 December 2020

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.

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12 December 2020

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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12 December 2020

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

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12 December 2020

Evidence that the Pim1 kinase gene is a direct target of HOXA9

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12 December 2020

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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12 December 2020

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

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12 December 2020

Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

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12 December 2020

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

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12 December 2020

An RNA polymerase II elongation factor encoded by the human ELL gene

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12 December 2020

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

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12 December 2020

Regulation of MLL1 H3K4 methyltransferase activity by its core components

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12 December 2020

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

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12 December 2020

Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

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12 December 2020

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

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12 December 2020

Interaction of MLL amino terminal sequences with menin is required for transformation

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12 December 2020

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

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12 December 2020

The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex

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12 December 2020

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

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12 December 2020

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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12 December 2020

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

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12 December 2020

Defects in yolk sac hematopoiesis in Mll-null embryos.

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12 December 2020

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

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12 December 2020

The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells

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12 December 2020

Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1

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12 December 2020

MLL associates specifically with a subset of transcriptionally active target genes

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12 December 2020

MLL fusion partners AF4 and AF9 interact at subnuclear foci

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12 December 2020

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

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12 December 2020

The diverse functions of histone lysine methylation

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12 December 2020

MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein

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12 December 2020

Global and Hox-specific roles for the MLL1 methyltransferase

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12 December 2020

Epigenetic regulation in Drosophila.

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12 December 2020

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

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12 December 2020

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

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12 December 2020

Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia: a recurrent cytogenetic association

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12 December 2020

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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12 December 2020

FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer

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12 December 2020

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

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12 December 2020

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

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12 December 2020

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges

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12 December 2020

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

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12 December 2020

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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12 December 2020

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

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12 December 2020

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

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12 December 2020

HOXA9 gene expression in the chronic myeloid leukemia progression

1 reference

12 December 2020

10.1007/S12185-007-0009-8

Identifiers

DOI

1 reference

17 September 2017

1 reference

PubMed ID

18224408