(Q40140184)

17 September 2017

title

The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms (English)

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17 September 2017

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1

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17 September 2017

Sophie Clément

2

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17 September 2017

Paolo Pugnale

3

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17 September 2017

Stéphanie Conzelman

4

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17 September 2017

Michelangelo Foti

5

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17 September 2017

Alessandra Mangia

6

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17 September 2017

Francesco Negro

7

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17 September 2017

language of work or name

English

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publication date

1 May 2007

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17 September 2017

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17 September 2017

volume

45

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17 September 2017

issue

5

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17 September 2017

page(s)

1164-1171

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Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States

17 September 2017

cites work

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Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3

21 January 2018

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Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes

21 January 2018

1 reference

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

1 reference

Global epidemiology of hepatitis C virus infection

21 January 2018

1 reference

7 January 2021

Extrahepatic manifestations of infection with hepatitis C virus

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7 January 2021

Association of diabetes mellitus and chronic hepatitis C virus infection.

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7 January 2021

High prevalence of hepatitis C virus infection in diabetic patients

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7 January 2021

Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study

1 reference

7 January 2021

Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status

1 reference

7 January 2021

Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected].

1 reference

7 January 2021

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.

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7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C

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7 January 2021

Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients

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7 January 2021

Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients.

1 reference

7 January 2021

An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation

1 reference

7 January 2021

SOCS-3 is an insulin-induced negative regulator of insulin signaling

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7 January 2021

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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7 January 2021

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

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7 January 2021

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

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7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 January 2021

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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7 January 2021

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

1 reference

7 January 2021

Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection

1 reference

7 January 2021

Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C: possible involvement in resistance to interferon therapy.

1 reference

7 January 2021

Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1

1 reference

7 January 2021

Inhibition of the proteasome as a therapeutic approach

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7 January 2021

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

7 January 2021

Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication

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7 January 2021

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

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7 January 2021

Increased risk of type 2 diabetes in noncirrhotic patients with chronic hepatitis C virus infection

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7 January 2021

Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study

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7 January 2021

Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance

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7 January 2021

SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function

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7 January 2021

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.

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7 January 2021

Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression

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7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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7 January 2021

Signaling by type I and II cytokine receptors: ten years after

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7 January 2021

Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C.

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7 January 2021

Identifiers

DOI

10.1002/HEP.21634

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17 September 2017

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