(Q40144631)

17 September 2017

1 reference

title

New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus (English)

1 reference

17 September 2017

1

R A DeFronzo

1 reference

17 September 2017

2

E Ferrannini

1 reference

17 September 2017

V. Koivisto

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6337486

1 October 2023

language of work or name

English

0 references

publication date

1 January 1983

1 reference

17 September 2017

17 January 1983

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6337486

full work available at URL

1 October 2023

number of pages

30

1 reference

based on heuristic

inferred from page(s)

https://api.elsevier.com/content/article/PII:000293438390654X?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90654-X

https://api.elsevier.com/content/article/PII:000293438390654X?httpAccept=text/plain

1 October 2023

1 reference

https://api.crossref.org/works/10.1016/0002-9343(83)90654-X

American Journal of Medicine

1 October 2023

published in

1 reference

17 September 2017

volume

74

1 reference

17 September 2017

issue

1A

1 reference

17 September 2017

page(s)

52-81

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Dose-response relation between plasma-insulin and blood-glucose levels during oral glucose loads in prediabetic and diabetic subjects

17 September 2017

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Insulin excess as the initial lesion in diabetes

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Influence of Maturity-onset Diabetes on Splanchnic Glucose Balance After Oral Glucose Ingestion

1 October 2023

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The Banting Memorial Lecture 1978. Clinical and etiologic heterogeneity of idiopathic diabetes mellitus

1 October 2023

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Heterogeneity of insulin responses in latent diabetes

1 October 2023

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The various faces of diabetes in the young: changing concepts

1 October 2023

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Secretion of insulin induced by amino acids and glucose in diabetes mellitus

1 October 2023

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1 October 2023

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1 October 2023

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Diabetes, blood lipids, lipoproteins, and change of environment: Restudy of the “new immigrant Yemenites” in Israel

1 October 2023

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1 October 2023

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1 October 2023

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Ten-year follow-up of subjects with impaired glucose tolerance: prevention of diabetes by tolbutamide and diet regulation.

1 October 2023

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Insulin Patterns in Equivocal Glucose Tolerance Tests (Chemical Diabetes)

1 October 2023

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Criteria for interpretation of the oral glucose tolerance tests in children and insulin responses with normal and abnormal tolerance

1 October 2023

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Is there a Delay in the Plasma Insulin Response of Patients with Chemical Diabetes Mellitus?

1 October 2023

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Insulin Responses of Children with Chemical Diabetes Mellitus

1 October 2023

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Adult-onset diabetes mellitus in childhood

1 October 2023

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Chemical diabetes mellitus in the child

1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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Locating the site(s) of insulin resistance in patients with nonketotic diabetes mellitus.

1 October 2023

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1 October 2023

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Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes

1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes

1 October 2023

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1 October 2023

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1 October 2023

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Influence of plasma glucose and insulin concentration on plasma glucose clearance in man

1 October 2023

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1 October 2023

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Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus

1 October 2023

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Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus.

1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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1 October 2023

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Influence of Oral Glucose Ingestion on Splanchnic Glucose and Gluconeogenic Substrate Metabolism in Man

1 October 2023

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1 October 2023

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Integrated control of hepatic glucose metabolism

1 October 2023

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Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange

1 October 2023

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The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man

1 October 2023

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Lack of a gastrointestinal mediator of insulin action in maturity-onset diabetes

1 October 2023

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Hepatic parasympathetic neuropathy as cause of maturity-onset diabetes?

1 October 2023

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The Glucose Uptake of Human Adipose Tissue in Obesity

1 October 2023

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1 October 2023

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Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction

1 October 2023

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Membrane Receptors for Polypeptide Hormones

1 October 2023

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Insulin binding to human adipocytes during late pregnancy in healthy, obese and diabetic state

1 October 2023

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1 October 2023

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1 October 2023

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Insulin Receptors in the Heart Muscle: Demonstration of Specific Binding Sites and Impairment of Insulin Binding in the Plasma Membrane of the Obese Hyperglycemic Mouse

1 October 2023

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Insulin binding and effects in isolated soleus muscle of lean and obese mice

1 October 2023

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Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action

1 October 2023

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Decreased insulin binding to adipocytes and circulating monocytes from obese subjects

1 October 2023

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Insulin-dependent regulation of the insulin-sensitivity of adipocytes

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1 October 2023

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Short-term regulation of insulin receptor affinity in man

1 October 2023

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The pathogenic role of an insulin-receptor defect in diabetes mellitus of the obese

1 October 2023

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Insulin receptors in hepatocytes: postreceptor events mediate down regulation.

1 October 2023

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Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats

1 October 2023

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Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

1 October 2023

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Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency

1 October 2023

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Department of Medicina, Faculdade de Medicina da Universidade de São Paulo, Brazil

1 October 2023

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Diet-Induced Improvement of Abnormalities in Insulin and Glucagon Secretion and in Insulin Receptor Binding in Diabetes Mellitus*

1 October 2023

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Diminished effect of caloric restriction on control of hyperglycemia with increasing known duration of type II diabetes mellitus.

1 October 2023

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Maturity onset diabetes mellitus: response to intensive dietary management

1 October 2023

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Insulin secretion improves following dietary control of plasma glucose in severely hyperglycemic obese patients.

1 October 2023

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The hypoglycemic sulfonamides: history and development of the problem from 1942 to 1955

1 October 2023

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Quantitative effects of glucose, sulfonylureas, salicylate, and indole-3-acetic acid on the secretion of insulin activity into pancreatic venous blood

1 October 2023

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The pattern of rsponse of plasma insulin and glucose to meals and fasting during chlorpropamide therapy.

1 October 2023

125

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Treatment of the obese diabetic. A comparative study of placebo, sulfonylurea and phenformin

1 October 2023

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Glipizide versus tolbutamide, an open trial. Effects on insulin secretory patterns and glucose concentrations

1 October 2023

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Clinical pharmacology of sulphonylurea hypoglycaemic agents: part 1.

1 October 2023

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Sulfonylurea treatment of insulin-independent diabetes mellitus

1 October 2023

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Extrapancreatic and pancreatic actions of glibenclamide in rats

1 October 2023

130

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Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels

1 October 2023

132

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Effect of two sulphonylureas on the dose kinetics of glucose-induced insulin release in normal and diabetic subjects

1 October 2023

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Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas

1 October 2023

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The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.

1 October 2023

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The stimulus-secretion coupling of glucose-induced insulin release-XVII. Effects of sulfonylureas and diazoxide on insular biosynthetic activity

1 October 2023

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Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans

1 October 2023

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Effect of glipizide on the release of insulin in the perfused rat pancreas in vitro

1 October 2023

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Dynamics of Tolbutamide, Glucose, and Insulin Interrelationships Following Varying Doses of Intravenous Tolbutamide in Normal Subjects

1 October 2023

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1 October 2023

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The effects of long-term acetohexamide treatment on pancreatic islet cell function in maturity-onset diabetes

1 October 2023

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Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets

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Electrical activity in pancreatic islet cells

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The kinetics of electrical activity of beta cells in response to a "square wave" stimulation with glucose or glibenclamide

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The stimulus-secretion coupling of glucose-induced insulin release XII. Effects of diazoxide and gliclazide upon45calcium efflux from perifused islets

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Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets

1 October 2023

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Effect of short and long term chlorpropamide treatment of insulin release and blood-glucose

1 October 2023

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Plasma insulin and glucose levels in maturity onset diabetics treated with chlorpropamide

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The effect of chronic oral antidiabetic therapy on insulin and glucagon responses to a meal

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Action of the hypoglycemic sulfonyl compounds in hypophysectomized, adrenalectomized, and depancreatized animals

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POTENTIATION OF INSULIN ACTION ON THE LIVER BY TOLBUTAMIDE

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Long-term studies of the sulfonylureas in totally depancreatized dogs

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Selective potentiation of insulin-mediated glucose disposal in normal dogs by the sulfonylurea glipizide

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Action of oral antidiabetic drugs on carbohydrate metabolism of isolated rat diaphragm

1 October 2023

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An insulin dependent effect of chronic tolbutamide administration on the skeletal muscle carbohydrate transport system

1 October 2023

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Compounds administered orally in the treatment of diabetes mellitus

1 October 2023

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Hepatic Effects of Chlorpropamide: Inhibition of Glucagon-stimulated Gluconeogenesis in Perfused Livers of Fasted Rats

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1 October 2023

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Effects of substituted sulfonylureas on rat diaphragm and liver tissue

1 October 2023

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The Acute Effects of Tolbutamide on Forearm Metabolism

1 October 2023

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Increased insulin sensitivity and cellular insulin binding in obese diabetics following treatment with glibenclamide

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Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients

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Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors

1 October 2023

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Sulphonylureas increase the number of insulin receptors

1 October 2023

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Sulphonylureas increase the number of insulin receptors

1 October 2023

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Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

1 October 2023

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Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay

1 October 2023

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STUDIES OF INSULIN AND GROWTH HORMONE SECRETION IN HUMAN OBESITY

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The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1 October 2023

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1 October 2023

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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1 October 2023

198

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The hormonal profile in obesity

1 October 2023

199

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Insulin response to glucagon. The opposing effects of diabetes and obesity

1 October 2023

200

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Effect of Diet Composition on the Hyperinsulinemia of Obesity

1 October 2023

201

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Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects

1 October 2023

202

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Insulin secretion in obesity

1 October 2023

203

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Relationship between in Vivo Insulin Resistance and Decreased Insulin Receptors in Obese Man*

1 October 2023

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Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism

1 October 2023

205

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Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding

1 October 2023

206

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Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects

1 October 2023

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The insulin receptor: its role in insulin resistance of obesity and diabetes

1 October 2023

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Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects

1 October 2023

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Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting

1 October 2023

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Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects

1 October 2023

211

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Metabolic Effects of Weight Loss in Obese Subjects: Changes in Plasma Substrate Levels, Insulin and Growth Hormone Responses

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Effect of weight changes on serum insulin response in subjects with normal oral glucose tolerance

1 October 2023

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Nitrogen Metabolism and Insulin Requirements in Obese Diabetic Adults on a Protein-Sparing Modified Fast

1 October 2023

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Effect of carbohydrate restriction in obese diabetics: relationship of control to weight loss.

1 October 2023

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Effects of dietary changes on cellular insulin binding and in vivo insulin sensitivity

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EFFECT OF PROLONGED CARBOHYDRATE RESTRICTION ON SERUM-INSULIN LEVELS IN MILD DIABETES

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1 October 2023

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Effect of a 3-day fast on glucose storage and oxidation in obese hyperinsulinemic diabetics.

1 October 2023

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Suppression of insulin secretion by protein deprivation in obesity

1 October 2023

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Glucose storage and oxidation in different degrees of human obesity measured by continuous indirect calorimetry

1 October 2023

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Increased plasma glucose and insulin responses to high-carbohydrate feedings in normal subjects

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Effect of a High Carbohydrate Diet on Insulin Binding to Adipocytes and on Insulin Action in vivo in Man

1 October 2023

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Basal and Postprotein Insulin and Glucagon Levels During a High and Low Carbohydrate Intake and Their Relationships to Plasma Triglycerides

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Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats

1 October 2023

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The influence of the antecedent diet upon glucagon and insulin secretion

1 October 2023

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Dietary Diabetes: The Influence of a Low Carbohydrate Diet on Forearm Metabolism in Man

1 October 2023

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Effects of low-carbohydrate diet and diabetes mellitus on plasma concentrations of glucose, non-esterified fatty acid, and insulin during oral glucose-tolerance tests

1 October 2023

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Improved Glucose Tolerance with High Carbohydrate Feeding in Mild Diabetes

1 October 2023

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Diabetes and atherosclerosis ? The role of insulin

1 October 2023

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Effect of a fat free, high carbohydrate diet on diabetic subjects with fasting hyperglycemia.

1 October 2023

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The effects of energy and carbohydrate restriction in patients with chronic diabetes mellitus

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Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects

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Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma-sugar, and plasma-insulin during oral carbohydrate tolerance tests

1 October 2023

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Fructose and the dietary therapy of diabetes mellitus

1 October 2023

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Some effects, in man, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood

1 October 2023

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A comparison of carbohydrate metabolism after sucrose, sorbitol, and fructose meals in normal and diabetic subjects

1 October 2023

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Effects of dietary fructose and sucrose on plasma triglyceride metabolism in patients with endogenous hypertriglyceridemia

1 October 2023

245

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Decrease in postprandial insulin and glucose concentrations by guar and pectin

1 October 2023

246

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Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men

1 October 2023

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High-Fiber Diets in the Treatment of Diabetes Mellitus

1 October 2023

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Effect of added fiber on the glucose and metabolic response to a mixed meal in normal and diabetic subjects

1 October 2023

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Glucose Tolerance and Blood Lipids in Bran-Fed Patients with Impaired Glucose Tolerance

1 October 2023

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Letter: Food: influence of form on absorption

1 October 2023

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Effect of physical training on cardiovascular adjustments to exercise in man

1 October 2023

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1 October 2023

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Keeping in step: does exercise benefit the diabetic?

1 October 2023

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Exercise in the treatment of obesity

1 October 2023

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The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm

1 October 2023

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Human Forearm Muscle Metabolism during Exercise: V. Quantitative Aspects of Glucose Uptake and Lactate Production during Prolonged Exercise

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OBSERVATIONS ON CEREBRAL CARBOHYDRATE METABOLISM IN MAN.

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Brain substrate utilization during prolonged exercise.

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Glucose metabolism during leg exercise in man

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1 October 2023

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Metabolism of Free Fatty Acids and Ketone Bodies During Exercise in Normal and Diabetic Man

1 October 2023

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Exercise and Diabetes Mellitus

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Plasma insulin concentrations during prolonged work at near maximal oxygen uptake

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Plasma glucagon levels in exercising man.

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Glucagon and plasma catecholamine responses to graded and prolonged exercise in man.

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Catecholamines and exercise

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Effect of exercise on the secretion and metabolism of cortisol in man

1 October 2023

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Response of growth hormone (GH), FFA, blood sugar and insulin to exercise in obese patients and normal subjects

1 October 2023

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Insulin in Plasma and Lymph and Tissue Glucose Uptake in the Exercising Hind Limb of the Dog

1 October 2023

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Action of muscular work on transfer of sugars across cell barriers; comparison with action of insulin

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Humoral nature of the hypoglycemic factor of muscular work

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Substrate utilization by the inactive leg during one-leg or arm exercise

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EFFECT OF EXERCISE ON THE PERIPHERAL UTILIZATION OF GLUCOSE IN MAN

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Determination of Leg Blood Flow During Exercise in Man: An Indicator-Dilution Technique Based on Femoral Venous Dye Infusion

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Regulation of the circulation during exercise in man

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Enhanced permeability to sugar associated with muscle contraction. Studies of the role of Ca++

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Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin

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Physical exercise and fuel homeostasis in diabetes mellitus

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Exercise, Insulin and Glucose Turnover in Dogs

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Synergistic interaction between exercise and insulin on peripheral glucose uptake

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Muscular exercise and metabolism in male juvenile diabetics. I. Energy metabolism during exercise

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The Effect of Exercise on Insulin Action in Diabetes.

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Influence of Intravenous Glucose Administration on Metabolism During Physical Exercise

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THE EFFECTS OF EXERCISE UPON DIABETIC CONTROL

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Muscular Exercise and Metabolism in Male Juvenile Diabetics II. Glucose Tolerance after Exercise

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Decline of the blood glucose concentration after muscular effort in diabetic children

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Blood Glucose Levels During Walking in Normal and Diabetic Subjects

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Effect of Exercise on Glucose and Insulin Response to Glucose Infusion

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Diminished insulin response in highly trained athletes

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Effects of physical training and adiposity on glucose metabolism and 125I-insulin binding

1 October 2023

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The effect of physical training on insulin production in obesity

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Identifiers

1 reference

17 September 2017

1 reference