(Q40145551)

17 September 2017

Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants (English)

1 reference

17 September 2017

Qiaojie Xiong

1

1 reference

PubMed ID

17435769

17 September 2017

Haiyan Sun

series ordinal

2

1 reference

PubMed ID

17435769

17 September 2017

Min Li

series ordinal

3

1 reference

17 September 2017

15 April 2007

1 reference

17 September 2017

Nature Chemical Biology

1 reference

17 September 2017

3

1 reference

17 September 2017

5

1 reference

17 September 2017

287-296

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio874

17 September 2017

0 references

cites work

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Cloned potassium channels from eukaryotes and prokaryotes

21 January 2018

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How far will you go to sense voltage?

21 January 2018

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21 January 2018

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Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

21 January 2018

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Neuronal KCNQ potassium channels: physiology and role in disease.

21 January 2018

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KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy

21 January 2018

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A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

21 January 2018

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International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

21 January 2018

1 reference

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KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

21 January 2018

1 reference

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A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

21 January 2018

1 reference

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Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

21 January 2018

1 reference

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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

21 January 2018

1 reference

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Ion channel genes and human neurological disease: recent progress, prospects, and challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Time course of TEA(+)-induced anomalous rectification in squid giant axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Enzymatic activation of voltage-gated potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Structural characterization of bis(N-oxopyridine-2-thionato)zinc(II)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

A potassium channel mutation in neonatal human epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Atomic proximity between S4 segment and pore domain in Shaker potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

The effects of a shampoo containing zinc pyrithione on the control of dandruff

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO874

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO874

1 reference

17 September 2017

1 reference

PubMed ID

17435769